Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice

Non-alcoholic steatohepatitis (NASH) is characterized by lipid accumulation in hepatocytes and inflammatory cell infiltration. In view of the anti-oxidative and anti-inflammatory effects of polydatin, the current study aimed to investigate the pharmacological effects of polydatin on NASH and its rel...

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Veröffentlicht in:	International journal of biological sciences 2018-01, Vol.14 (11), p.1411-1425
Hauptverfasser:	Li, Rui, Li, Jingzhi, Huang, Yiji, Li, Hui, Yan, Sishan, Lin, Jiaxin, Chen, Ying, Wu, Limin, Liu, Bing, Wang, Genshu, Lan, Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alanine Alanine transaminase Apoptosis Aspartate aminotransferase Caspase Caspase-3 Cell activation Chemical compounds Choline Diet Fibrosis Gene expression Hepatocytes Immune system Infiltration Inflammation Lipids Lipopolysaccharides Liver Macrophages Methionine Mice NF-κB protein NOX4 protein Nutrient deficiency Oxidative stress Palmitic acid Pharmacology Proteins Reduction Research Paper Signal transduction Toll-like receptors
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