DNA base sequence effects on bulky lesion-induced conformational heterogeneity during DNA replication

Abstract 4-Aminobiphenyl (ABP) and its structure analog 2-aminofluorene (AF) are well-known carcinogens. In the present work, an unusual sequence effect in the 5′-CTTCTG1G2TCCTCATTC-3′ DNA duplex is reported for ABP- and AF-modified G. Specifically, the ABP modification at G1 resulted in a mixture o...

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Veröffentlicht in:	Nucleic acids research 2018-07, Vol.46 (12), p.6356-6370
Hauptverfasser:	Cai, Ang, Wilson, Katie A, Patnaik, Satyakam, Wetmore, Stacey D, Cho, Bongsup P
Format:	Artikel
Sprache:	eng
Schlagworte:	Structural Biology
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