USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1

The host intrinsic innate immune system drives antiviral defenses and viral restriction, which includes the production of soluble factors, such as type I and III interferon (IFN), and activation of restriction factors, including SAMHD1, a deoxynucleoside triphosphohydrolase. Interferon-stimulated ge...

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Veröffentlicht in:	Journal of virology 2018-10, Vol.92 (20)
Hauptverfasser:	Osei Kuffour, Edmund, Schott, Kerstin, Jaguva Vasudevan, Ananda Ayyappan, Holler, Jessica, Schulz, Wolfgang A, Lang, Philipp A, Lang, Karl S, Kim, Baek, Häussinger, Dieter, König, Renate, Münk, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclin-Dependent Kinase Inhibitor p21 - metabolism Endopeptidases - genetics Endopeptidases - metabolism Gene Knockout Techniques HIV-1 - immunology Humans Immunity, Innate Macrophages - immunology Macrophages - virology THP-1 Cells Virus-Cell Interactions
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