Persistent effects of obesity: a neuroplasticity hypothesis

The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose weight through changes in diet and lifestyle, keeping the weight off remains a challenge. Here, we discuss a hypothes...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2018-09, Vol.1428 (1), p.221-239
Hauptverfasser:	Matikainen‐Ankney, Bridget A., Kravitz, Alexxai V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Body weight Body weight loss Cardiovascular diseases Circuits Comorbidity Corpus Striatum - physiopathology Diet, High-Fat - adverse effects Dopamine - physiology Drug abuse Energy balance Energy Metabolism - physiology Energy storage Epidemics Exercise - physiology Exercise - psychology Feeding Behavior - physiology glutamate Glutamates - physiology Health problems Health risks high‐fat diet Humans Hypothalamus - physiopathology Hypotheses Inflammation Mental disorders Motivation Motivation - physiology Nerve Net - physiology Neural Pathways - physiology Neuronal Plasticity Neuroplasticity Obesity Obesity - epidemiology Obesity - metabolism Obesity - physiopathology Obesity - psychology Physical activity plasticity Rats Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - physiology Receptors, Opioid - physiology Recurrence Substance use Substance-Related Disorders - epidemiology Substance-Related Disorders - physiopathology Substance-Related Disorders - psychology synaptic Ventral Tegmental Area - physiopathology Weight control Weight loss Weight Loss - physiology
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