Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients
The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admissi...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2018-10, Vol.22 (10), p.4732-4737 |
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| creator | Costa, Nara Aline Gut, Ana Lúcia Azevedo, Paula Schmidt Polegato, Bertha Furlan Magalhães, Eloá Siqueira Ishikawa, Larissa Lumi Watanabe Bruder, Rita de Cassia Siqueira Silva, Evelyn Aparecida da Gonçalves, Renan Braga Tanni, Suzana Erico Rogero, Marcelo Macedo Norde, Marina Maintinguer Cunha, Natália Baraldi Zornoff, Leonardo Antonio Mamede Paiva, Sergio Alberto Rupp Minicucci, Marcos Ferreira |
| description | The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentrations and its polymorphism PADI4_89 [rs11203366], PADI4_94 [rs2240340] and PADI4_104 [rs1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment (SOFA) scores. In addition, PAD4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI4 polymorphisms and ICU mortality. In the logistic regression models, PAD4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate (OR: 1.477; CI 95%: 1.186‐1.839; P |
| doi_str_mv | 10.1111/jcmm.13717 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6156447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2076242328</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3447-68ea3faab4808f6bcc9e5cbeba9e915408eed3adb3b285143b29ad936ac07f1a3</originalsourceid><addsrcrecordid>eNpVkU9v1DAQxS0Eon_gwgdAPnLoFjt2EueCVC0UFrWiB3q2Js5sd0pih9hLlSufHG93qWAuM9I8_Z49j7E3UpzLXO_v3TCcS1XL-hk7lqUpFrpR-vlhlkaZI3YS470QqpKqecmOlBBal0ods983OCbq5h6mO_LkkXdIA3mIyDV3wTv0aYJEwZ_xdpu4D4nfXHxcaT6Gfh7CNG4oDvGMU-QQY3AECTv-QGnDV8tbnhUJekozJ8_jzszxuAnuBx8zNcPjK_ZiDX3E14d-ym4vP31ffllcffu8Wl5cLUaldb2oDIJaA7TaCLOuWucaLF2LLTTYyFILg9gp6FrVFqaUOrcGukZV4ES9lqBO2Yc9d9y2A3b7j_V2nGiAabYByP6_8bSxd-GXrWRZ5RdkwLsDYAo_txiTHSg67HvwGLbRFqKuCl2owmTp23-9nkz-Hj4L5F7wQD3OT3sp7C5Su4vUPkZqvy6vrx8n9Qc2ZZhY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2076242328</pqid></control><display><type>article</type><title>Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Costa, Nara Aline ; Gut, Ana Lúcia ; Azevedo, Paula Schmidt ; Polegato, Bertha Furlan ; Magalhães, Eloá Siqueira ; Ishikawa, Larissa Lumi Watanabe ; Bruder, Rita de Cassia Siqueira ; Silva, Evelyn Aparecida da ; Gonçalves, Renan Braga ; Tanni, Suzana Erico ; Rogero, Marcelo Macedo ; Norde, Marina Maintinguer ; Cunha, Natália Baraldi ; Zornoff, Leonardo Antonio Mamede ; Paiva, Sergio Alberto Rupp ; Minicucci, Marcos Ferreira</creator><creatorcontrib>Costa, Nara Aline ; Gut, Ana Lúcia ; Azevedo, Paula Schmidt ; Polegato, Bertha Furlan ; Magalhães, Eloá Siqueira ; Ishikawa, Larissa Lumi Watanabe ; Bruder, Rita de Cassia Siqueira ; Silva, Evelyn Aparecida da ; Gonçalves, Renan Braga ; Tanni, Suzana Erico ; Rogero, Marcelo Macedo ; Norde, Marina Maintinguer ; Cunha, Natália Baraldi ; Zornoff, Leonardo Antonio Mamede ; Paiva, Sergio Alberto Rupp ; Minicucci, Marcos Ferreira</creatorcontrib><description>The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentrations and its polymorphism PADI4_89 [rs11203366], PADI4_94 [rs2240340] and PADI4_104 [rs1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment (SOFA) scores. In addition, PAD4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI4 polymorphisms and ICU mortality. In the logistic regression models, PAD4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate (OR: 1.477; CI 95%: 1.186‐1.839; P < .001), and when adjusted for age, gender and APACHE II score (OR: 1.392; CI 95%: 1.145‐1.692; P < .001). In conclusion, PAD4 concentration, but not PADI4_89, PADI4_94 and PADI4_104 polymorphisms, is associated with ICU mortality in septic shock patients.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.13717</identifier><identifier>PMID: 30044533</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Aged ; APACHE ; citrullination ; Female ; Gene Expression ; Hospital Mortality - trends ; Humans ; Intensive Care Units ; Male ; Middle Aged ; neutrophils extracellular traps ; Original ; peptidylarginine deiminase 4 ; Polymorphism, Single Nucleotide ; Prospective Studies ; Protein-Arginine Deiminase Type 4 ; Protein-Arginine Deiminases - blood ; Protein-Arginine Deiminases - genetics ; sepsis ; Shock, Septic - blood ; Shock, Septic - genetics ; Shock, Septic - mortality ; Shock, Septic - pathology ; single nucleotide polymorphisms ; Survival Analysis</subject><ispartof>Journal of cellular and molecular medicine, 2018-10, Vol.22 (10), p.4732-4737</ispartof><rights>2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5980-4367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156447/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156447/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30044533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Nara Aline</creatorcontrib><creatorcontrib>Gut, Ana Lúcia</creatorcontrib><creatorcontrib>Azevedo, Paula Schmidt</creatorcontrib><creatorcontrib>Polegato, Bertha Furlan</creatorcontrib><creatorcontrib>Magalhães, Eloá Siqueira</creatorcontrib><creatorcontrib>Ishikawa, Larissa Lumi Watanabe</creatorcontrib><creatorcontrib>Bruder, Rita de Cassia Siqueira</creatorcontrib><creatorcontrib>Silva, Evelyn Aparecida da</creatorcontrib><creatorcontrib>Gonçalves, Renan Braga</creatorcontrib><creatorcontrib>Tanni, Suzana Erico</creatorcontrib><creatorcontrib>Rogero, Marcelo Macedo</creatorcontrib><creatorcontrib>Norde, Marina Maintinguer</creatorcontrib><creatorcontrib>Cunha, Natália Baraldi</creatorcontrib><creatorcontrib>Zornoff, Leonardo Antonio Mamede</creatorcontrib><creatorcontrib>Paiva, Sergio Alberto Rupp</creatorcontrib><creatorcontrib>Minicucci, Marcos Ferreira</creatorcontrib><title>Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentrations and its polymorphism PADI4_89 [rs11203366], PADI4_94 [rs2240340] and PADI4_104 [rs1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment (SOFA) scores. In addition, PAD4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI4 polymorphisms and ICU mortality. In the logistic regression models, PAD4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate (OR: 1.477; CI 95%: 1.186‐1.839; P < .001), and when adjusted for age, gender and APACHE II score (OR: 1.392; CI 95%: 1.145‐1.692; P < .001). In conclusion, PAD4 concentration, but not PADI4_89, PADI4_94 and PADI4_104 polymorphisms, is associated with ICU mortality in septic shock patients.</description><subject>Aged</subject><subject>APACHE</subject><subject>citrullination</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neutrophils extracellular traps</subject><subject>Original</subject><subject>peptidylarginine deiminase 4</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Protein-Arginine Deiminase Type 4</subject><subject>Protein-Arginine Deiminases - blood</subject><subject>Protein-Arginine Deiminases - genetics</subject><subject>sepsis</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - genetics</subject><subject>Shock, Septic - mortality</subject><subject>Shock, Septic - pathology</subject><subject>single nucleotide polymorphisms</subject><subject>Survival Analysis</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpVkU9v1DAQxS0Eon_gwgdAPnLoFjt2EueCVC0UFrWiB3q2Js5sd0pih9hLlSufHG93qWAuM9I8_Z49j7E3UpzLXO_v3TCcS1XL-hk7lqUpFrpR-vlhlkaZI3YS470QqpKqecmOlBBal0ods983OCbq5h6mO_LkkXdIA3mIyDV3wTv0aYJEwZ_xdpu4D4nfXHxcaT6Gfh7CNG4oDvGMU-QQY3AECTv-QGnDV8tbnhUJekozJ8_jzszxuAnuBx8zNcPjK_ZiDX3E14d-ym4vP31ffllcffu8Wl5cLUaldb2oDIJaA7TaCLOuWucaLF2LLTTYyFILg9gp6FrVFqaUOrcGukZV4ES9lqBO2Yc9d9y2A3b7j_V2nGiAabYByP6_8bSxd-GXrWRZ5RdkwLsDYAo_txiTHSg67HvwGLbRFqKuCl2owmTp23-9nkz-Hj4L5F7wQD3OT3sp7C5Su4vUPkZqvy6vrx8n9Qc2ZZhY</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Costa, Nara Aline</creator><creator>Gut, Ana Lúcia</creator><creator>Azevedo, Paula Schmidt</creator><creator>Polegato, Bertha Furlan</creator><creator>Magalhães, Eloá Siqueira</creator><creator>Ishikawa, Larissa Lumi Watanabe</creator><creator>Bruder, Rita de Cassia Siqueira</creator><creator>Silva, Evelyn Aparecida da</creator><creator>Gonçalves, Renan Braga</creator><creator>Tanni, Suzana Erico</creator><creator>Rogero, Marcelo Macedo</creator><creator>Norde, Marina Maintinguer</creator><creator>Cunha, Natália Baraldi</creator><creator>Zornoff, Leonardo Antonio Mamede</creator><creator>Paiva, Sergio Alberto Rupp</creator><creator>Minicucci, Marcos Ferreira</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5980-4367</orcidid></search><sort><creationdate>201810</creationdate><title>Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients</title><author>Costa, Nara Aline ; Gut, Ana Lúcia ; Azevedo, Paula Schmidt ; Polegato, Bertha Furlan ; Magalhães, Eloá Siqueira ; Ishikawa, Larissa Lumi Watanabe ; Bruder, Rita de Cassia Siqueira ; Silva, Evelyn Aparecida da ; Gonçalves, Renan Braga ; Tanni, Suzana Erico ; Rogero, Marcelo Macedo ; Norde, Marina Maintinguer ; Cunha, Natália Baraldi ; Zornoff, Leonardo Antonio Mamede ; Paiva, Sergio Alberto Rupp ; Minicucci, Marcos Ferreira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3447-68ea3faab4808f6bcc9e5cbeba9e915408eed3adb3b285143b29ad936ac07f1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>APACHE</topic><topic>citrullination</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neutrophils extracellular traps</topic><topic>Original</topic><topic>peptidylarginine deiminase 4</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Protein-Arginine Deiminase Type 4</topic><topic>Protein-Arginine Deiminases - blood</topic><topic>Protein-Arginine Deiminases - genetics</topic><topic>sepsis</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - genetics</topic><topic>Shock, Septic - mortality</topic><topic>Shock, Septic - pathology</topic><topic>single nucleotide polymorphisms</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Nara Aline</creatorcontrib><creatorcontrib>Gut, Ana Lúcia</creatorcontrib><creatorcontrib>Azevedo, Paula Schmidt</creatorcontrib><creatorcontrib>Polegato, Bertha Furlan</creatorcontrib><creatorcontrib>Magalhães, Eloá Siqueira</creatorcontrib><creatorcontrib>Ishikawa, Larissa Lumi Watanabe</creatorcontrib><creatorcontrib>Bruder, Rita de Cassia Siqueira</creatorcontrib><creatorcontrib>Silva, Evelyn Aparecida da</creatorcontrib><creatorcontrib>Gonçalves, Renan Braga</creatorcontrib><creatorcontrib>Tanni, Suzana Erico</creatorcontrib><creatorcontrib>Rogero, Marcelo Macedo</creatorcontrib><creatorcontrib>Norde, Marina Maintinguer</creatorcontrib><creatorcontrib>Cunha, Natália Baraldi</creatorcontrib><creatorcontrib>Zornoff, Leonardo Antonio Mamede</creatorcontrib><creatorcontrib>Paiva, Sergio Alberto Rupp</creatorcontrib><creatorcontrib>Minicucci, Marcos Ferreira</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Nara Aline</au><au>Gut, Ana Lúcia</au><au>Azevedo, Paula Schmidt</au><au>Polegato, Bertha Furlan</au><au>Magalhães, Eloá Siqueira</au><au>Ishikawa, Larissa Lumi Watanabe</au><au>Bruder, Rita de Cassia Siqueira</au><au>Silva, Evelyn Aparecida da</au><au>Gonçalves, Renan Braga</au><au>Tanni, Suzana Erico</au><au>Rogero, Marcelo Macedo</au><au>Norde, Marina Maintinguer</au><au>Cunha, Natália Baraldi</au><au>Zornoff, Leonardo Antonio Mamede</au><au>Paiva, Sergio Alberto Rupp</au><au>Minicucci, Marcos Ferreira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2018-10</date><risdate>2018</risdate><volume>22</volume><issue>10</issue><spage>4732</spage><epage>4737</epage><pages>4732-4737</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentrations and its polymorphism PADI4_89 [rs11203366], PADI4_94 [rs2240340] and PADI4_104 [rs1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment (SOFA) scores. In addition, PAD4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI4 polymorphisms and ICU mortality. In the logistic regression models, PAD4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate (OR: 1.477; CI 95%: 1.186‐1.839; P < .001), and when adjusted for age, gender and APACHE II score (OR: 1.392; CI 95%: 1.145‐1.692; P < .001). In conclusion, PAD4 concentration, but not PADI4_89, PADI4_94 and PADI4_104 polymorphisms, is associated with ICU mortality in septic shock patients.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>30044533</pmid><doi>10.1111/jcmm.13717</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5980-4367</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged APACHE citrullination Female Gene Expression Hospital Mortality - trends Humans Intensive Care Units Male Middle Aged neutrophils extracellular traps Original peptidylarginine deiminase 4 Polymorphism, Single Nucleotide Prospective Studies Protein-Arginine Deiminase Type 4 Protein-Arginine Deiminases - blood Protein-Arginine Deiminases - genetics sepsis Shock, Septic - blood Shock, Septic - genetics Shock, Septic - mortality Shock, Septic - pathology single nucleotide polymorphisms Survival Analysis |
| title | Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients |
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