TRIM32 promotes cell proliferation and invasion by activating β‐catenin signalling in gastric cancer

The tripartite motif (TRIM) family comprises more than 70 members involved in the regulation of many cellular pathways. TRIM32 acts as an E3 ubiquitin ligase and has been reported to participate in many human cancers. Here, we aimed to investigate the role of TRIM32 in gastric cancer (GC) and the cl...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2018-10, Vol.22 (10), p.5020-5028
Hauptverfasser:	Wang, Changming, Xu, Jiapeng, Fu, Hongbing, Zhang, Yu, Zhang, Xin, Yang, Dejun, Zhu, Zhenxin, Wei, Ziran, Hu, Zunqi, Yan, Ronglin, Cai, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Axin Protein - genetics beta Catenin - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cyclin D1 - genetics Epithelial-Mesenchymal Transition - genetics Female gastric cancer Gene Expression Regulation, Neoplastic Hepatocyte Nuclear Factor 1-alpha - genetics Humans invasion Male Matrix Metalloproteinase 7 - genetics Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Original proliferation Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcription Factors - genetics TRIM32 Tripartite Motif Proteins - genetics Ubiquitin-Protein Ligases - genetics Wnt Signaling Pathway - genetics β‐catenin
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