The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management
To investigate the clinical characteristics and risk factors for miscarriage of intrauterine normal pregnancy of patients with a heterotopic pregnancy (HP) after treatment.This was a retrospective study of medical records from CHA Bundang Medical Center. Sixty-four patients who were diagnosed with a...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-09, Vol.97 (37), p.e12233-e12233 |
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| container_title | Medicine (Baltimore) |
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| creator | Na, Eun Duc Jung, Inkyung Choi, Dong Hee Kwon, Hwang Heo, Seok Jae Kim, Hyeon Chul Kang, Suk Ho Cho, HeeYoung |
| description | To investigate the clinical characteristics and risk factors for miscarriage of intrauterine normal pregnancy of patients with a heterotopic pregnancy (HP) after treatment.This was a retrospective study of medical records from CHA Bundang Medical Center. Sixty-four patients who were diagnosed with a HP between February 2006 and July 2017 were included in this study. All analyses were performed using SAS software, version 9.4 (SAS Institute, Inc., Cary, NC). P values |
| doi_str_mv | 10.1097/MD.0000000000012233 |
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Sixty-four patients who were diagnosed with a HP between February 2006 and July 2017 were included in this study. All analyses were performed using SAS software, version 9.4 (SAS Institute, Inc., Cary, NC). P values < .05 were considered statistically significant.Forty-eight patients had tubal ectopic pregnancies (EP), 10 patients had cornual EPs, 1 patient had a cesarean section scar EP, 4 patients had an ovarian EP, and 1 patient had bilateral tubal EP. Among the 64 patients, 14.1% (9/64) miscarried before 10 weeks of gestation after management. Mean gestational age (GA) at treatment was 5.97 ± 0.50 weeks and 6.80 ± 1.04 weeks for miscarriage and nonmiscarriage group, respectively (P = .008). Significant differences were observed between 2 groups in terms of ultrasonographic features at the time HP was diagnosed (P = .040) Logistic regression models indicated that gestational age at treatment showed significant differences between 2 groups (OR: 0.003, 95% CI: 0.001-0.604).Immediate management after diagnosis could expect favorable prognosis of HP. GA at treatment was the only independent risk factor for miscarriage in patients with HP regardless of treatment methods.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000012233</identifier><identifier>PMID: 30212954</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Abortion, Spontaneous - epidemiology ; Early Diagnosis ; Female ; Gestational Age ; Humans ; Observational Study ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pregnancy, Heterotopic - diagnosis ; Pregnancy, Heterotopic - epidemiology ; Pregnancy, Heterotopic - therapy ; Retrospective Studies ; Risk Factors ; Ultrasonography, Prenatal</subject><ispartof>Medicine (Baltimore), 2018-09, Vol.97 (37), p.e12233-e12233</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5161-ff7b30a97e8cf000cd290e7acba93b3d9084e14c3c05e9ca631e56f892a2f48b3</citedby><cites>FETCH-LOGICAL-c5161-ff7b30a97e8cf000cd290e7acba93b3d9084e14c3c05e9ca631e56f892a2f48b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156031/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156031/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30212954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Na, Eun Duc</creatorcontrib><creatorcontrib>Jung, Inkyung</creatorcontrib><creatorcontrib>Choi, Dong Hee</creatorcontrib><creatorcontrib>Kwon, Hwang</creatorcontrib><creatorcontrib>Heo, Seok Jae</creatorcontrib><creatorcontrib>Kim, Hyeon Chul</creatorcontrib><creatorcontrib>Kang, Suk Ho</creatorcontrib><creatorcontrib>Cho, HeeYoung</creatorcontrib><title>The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To investigate the clinical characteristics and risk factors for miscarriage of intrauterine normal pregnancy of patients with a heterotopic pregnancy (HP) after treatment.This was a retrospective study of medical records from CHA Bundang Medical Center. Sixty-four patients who were diagnosed with a HP between February 2006 and July 2017 were included in this study. All analyses were performed using SAS software, version 9.4 (SAS Institute, Inc., Cary, NC). P values < .05 were considered statistically significant.Forty-eight patients had tubal ectopic pregnancies (EP), 10 patients had cornual EPs, 1 patient had a cesarean section scar EP, 4 patients had an ovarian EP, and 1 patient had bilateral tubal EP. Among the 64 patients, 14.1% (9/64) miscarried before 10 weeks of gestation after management. Mean gestational age (GA) at treatment was 5.97 ± 0.50 weeks and 6.80 ± 1.04 weeks for miscarriage and nonmiscarriage group, respectively (P = .008). Significant differences were observed between 2 groups in terms of ultrasonographic features at the time HP was diagnosed (P = .040) Logistic regression models indicated that gestational age at treatment showed significant differences between 2 groups (OR: 0.003, 95% CI: 0.001-0.604).Immediate management after diagnosis could expect favorable prognosis of HP. GA at treatment was the only independent risk factor for miscarriage in patients with HP regardless of treatment methods.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Observational Study</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy, Heterotopic - diagnosis</subject><subject>Pregnancy, Heterotopic - epidemiology</subject><subject>Pregnancy, Heterotopic - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Ultrasonography, Prenatal</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhS0EosPAL0BCXrJJ8SNO4g0SanlJrdiUteV4riemjj3YTkfd88PxdEopeGPJ57vnXt-D0GtKTimR_bvL81Py91DGOH-CVlTwrhGya5-iFSFMNL3s2xP0IucfFeI9a5-jE04YZVK0K_TragKcXL7GVpsSU8bR4tllo1NyegtYhw2OYy5QkjPa47gUE2e441woSS8FkguAQ0xz1XcJtkEHc4tt9D7uXdjiCSoTS9w580ifdagNZgjlJXpmtc_w6v5eo--fPl6dfWkuvn3-evbhojGCdrSxth850bKHwdj6ZbNhkkCvzaglH_lGkqEF2hpuiABpdMcpiM4Okmlm22Hka_T-6Ltbxhk2Bg7ze7VLbtbpVkXt1L9KcJPaxhvVUdERTqvB23uDFH8ukIs6rAq81wHikhWjRJBuYDWENeJH1KSYcwL70IYSdchPXZ6r__OrVW8eT_hQ8yewCrRHYB99XWq-9ssekppA-zLd-YlesoYROhBJW9LUlzr4b55oqnc</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Na, Eun Duc</creator><creator>Jung, Inkyung</creator><creator>Choi, Dong Hee</creator><creator>Kwon, Hwang</creator><creator>Heo, Seok Jae</creator><creator>Kim, Hyeon Chul</creator><creator>Kang, Suk Ho</creator><creator>Cho, HeeYoung</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management</title><author>Na, Eun Duc ; Jung, Inkyung ; Choi, Dong Hee ; Kwon, Hwang ; Heo, Seok Jae ; Kim, Hyeon Chul ; Kang, Suk Ho ; Cho, HeeYoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5161-ff7b30a97e8cf000cd290e7acba93b3d9084e14c3c05e9ca631e56f892a2f48b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Observational Study</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy, Heterotopic - diagnosis</topic><topic>Pregnancy, Heterotopic - epidemiology</topic><topic>Pregnancy, Heterotopic - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Na, Eun Duc</creatorcontrib><creatorcontrib>Jung, Inkyung</creatorcontrib><creatorcontrib>Choi, Dong Hee</creatorcontrib><creatorcontrib>Kwon, Hwang</creatorcontrib><creatorcontrib>Heo, Seok Jae</creatorcontrib><creatorcontrib>Kim, Hyeon Chul</creatorcontrib><creatorcontrib>Kang, Suk Ho</creatorcontrib><creatorcontrib>Cho, HeeYoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Na, Eun Duc</au><au>Jung, Inkyung</au><au>Choi, Dong Hee</au><au>Kwon, Hwang</au><au>Heo, Seok Jae</au><au>Kim, Hyeon Chul</au><au>Kang, Suk Ho</au><au>Cho, HeeYoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>97</volume><issue>37</issue><spage>e12233</spage><epage>e12233</epage><pages>e12233-e12233</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To investigate the clinical characteristics and risk factors for miscarriage of intrauterine normal pregnancy of patients with a heterotopic pregnancy (HP) after treatment.This was a retrospective study of medical records from CHA Bundang Medical Center. Sixty-four patients who were diagnosed with a HP between February 2006 and July 2017 were included in this study. All analyses were performed using SAS software, version 9.4 (SAS Institute, Inc., Cary, NC). P values < .05 were considered statistically significant.Forty-eight patients had tubal ectopic pregnancies (EP), 10 patients had cornual EPs, 1 patient had a cesarean section scar EP, 4 patients had an ovarian EP, and 1 patient had bilateral tubal EP. Among the 64 patients, 14.1% (9/64) miscarried before 10 weeks of gestation after management. Mean gestational age (GA) at treatment was 5.97 ± 0.50 weeks and 6.80 ± 1.04 weeks for miscarriage and nonmiscarriage group, respectively (P = .008). Significant differences were observed between 2 groups in terms of ultrasonographic features at the time HP was diagnosed (P = .040) Logistic regression models indicated that gestational age at treatment showed significant differences between 2 groups (OR: 0.003, 95% CI: 0.001-0.604).Immediate management after diagnosis could expect favorable prognosis of HP. GA at treatment was the only independent risk factor for miscarriage in patients with HP regardless of treatment methods.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>30212954</pmid><doi>10.1097/MD.0000000000012233</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine (Baltimore), 2018-09, Vol.97 (37), p.e12233-e12233 |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Abortion, Spontaneous - epidemiology Early Diagnosis Female Gestational Age Humans Observational Study Pregnancy Pregnancy Outcome - epidemiology Pregnancy, Heterotopic - diagnosis Pregnancy, Heterotopic - epidemiology Pregnancy, Heterotopic - therapy Retrospective Studies Risk Factors Ultrasonography, Prenatal |
| title | The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management |
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