Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditi...

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Veröffentlicht in:	Scientific reports 2018-09, Vol.8 (1), p.14212-10, Article 14212
Hauptverfasser:	Yen, Kelvin, Wan, Junxiang, Mehta, Hemal H., Miller, Brendan, Christensen, Amy, Levine, Morgan E., Salomon, Matthew P., Brandhorst, Sebastian, Xiao, Jialin, Kim, Su-Jeong, Navarrete, Gerardo, Campo, Daniel, Harry, G. Jean, Longo, Valter, Pike, Christian J., Mack, Wendy J., Hodis, Howard N., Crimmins, Eileen M., Cohen, Pinchas
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 45 45/23 45/43 631/208/727/728 631/378/2612 64/60 Age Aging Animal models Animals Cell culture Cell Line, Tumor Cognition - physiology Cognitive ability Cognitive Dysfunction - genetics Female Genetics Genome, Mitochondrial - genetics Genomes Humanin Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - genetics Male Mice Mice, Inbred C57BL Middle Aged Mitochondria Mitochondria - genetics multidisciplinary Neural coding Neurodegenerative Diseases - genetics Neuroprotection Neuroprotective Agents - metabolism Older people Peptides Peptides - genetics Polymorphism, Single Nucleotide - genetics Science Science (multidisciplinary) Single-nucleotide polymorphism
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