Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7 Cells
We investigated the beneficial effects of the crude flake (CEF), which is a residual product after polyphenol extraction from , on inflammation in LPS-stimulated RAW264.7 cells. A group of five different CEF extracts was obtained by a preparation process using water, hydrochloric acid or temperature...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2017-05, Vol.22 (5), p.777 |
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| creator | Hwang, Ji-Hyun Kim, Kui-Jin Lee, Boo-Yong |
| description | We investigated the beneficial effects of the crude
flake (CEF), which is a residual product after polyphenol extraction from
, on inflammation in LPS-stimulated RAW264.7 cells. A group of five different CEF extracts was obtained by a preparation process using water, hydrochloric acid or temperature. We observed that large-size (>19 kDa) CEF extract, which was extracted with water at 95 °C (CEF-W, 95 °C), suppressed the production of inflammatory cytokines by inhibiting its mRNA expression in LPS-induced RAW264.7 cells. TLR4 signaling involvements were negatively regulated by CEF-W, 95 °C. CEF-W, 95 °C repressed the translocation of NF-κB from cytoplasm into nucleus in LPS-induced RAW264.7 cells. CEF-W, 95 °C attenuated the phosphorylation of TBK1 and IRF3 by inhibiting the phosphorylation of ERK. Taken together, we demonstrated that large-size CEF-W, 95 °C may act as a negative regulator of inflammation through the suppression of TLR4 signaling constituents in LPS-induced RAW264.7 cells. |
| doi_str_mv | 10.3390/molecules22050777 |
| format | Article |
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flake (CEF), which is a residual product after polyphenol extraction from
, on inflammation in LPS-stimulated RAW264.7 cells. A group of five different CEF extracts was obtained by a preparation process using water, hydrochloric acid or temperature. We observed that large-size (>19 kDa) CEF extract, which was extracted with water at 95 °C (CEF-W, 95 °C), suppressed the production of inflammatory cytokines by inhibiting its mRNA expression in LPS-induced RAW264.7 cells. TLR4 signaling involvements were negatively regulated by CEF-W, 95 °C. CEF-W, 95 °C repressed the translocation of NF-κB from cytoplasm into nucleus in LPS-induced RAW264.7 cells. CEF-W, 95 °C attenuated the phosphorylation of TBK1 and IRF3 by inhibiting the phosphorylation of ERK. Taken together, we demonstrated that large-size CEF-W, 95 °C may act as a negative regulator of inflammation through the suppression of TLR4 signaling constituents in LPS-induced RAW264.7 cells.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules22050777</identifier><identifier>PMID: 28489052</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Attenuation ; Cell Nucleus - drug effects ; Cell Nucleus - immunology ; Cell Nucleus - metabolism ; Complex Mixtures - isolation & purification ; Complex Mixtures - pharmacology ; Cytokines ; Cytoplasm ; Cytosol - drug effects ; Cytosol - immunology ; Cytosol - metabolism ; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases - genetics ; Extracellular Signal-Regulated MAP Kinases - immunology ; Extraction ; Gene expression ; Gene Expression Regulation ; Hydrochloric acid ; Inflammation ; Inflammation - prevention & control ; Interferon regulatory factor 3 ; Interferon Regulatory Factor-3 - antagonists & inhibitors ; Interferon Regulatory Factor-3 - genetics ; Interferon Regulatory Factor-3 - immunology ; Lipopolysaccharides ; Lipopolysaccharides - antagonists & inhibitors ; Lipopolysaccharides - pharmacology ; Mice ; NF-kappa B - antagonists & inhibitors ; NF-kappa B - genetics ; NF-kappa B - immunology ; Nuclei (cytology) ; Phaeophyceae - chemistry ; Phosphorylation ; Phosphorylation - drug effects ; Protein Serine-Threonine Kinases - antagonists & inhibitors ; Protein Serine-Threonine Kinases - genetics ; Protein Serine-Threonine Kinases - immunology ; Protein Transport ; RAW 264.7 Cells ; Signal Transduction ; Temperature effects ; TLR4 protein ; Toll-Like Receptor 4 - antagonists & inhibitors ; Toll-Like Receptor 4 - genetics ; Toll-Like Receptor 4 - immunology ; Toll-like receptors ; Translocation ; Water scarcity]]></subject><ispartof>Molecules (Basel, Switzerland), 2017-05, Vol.22 (5), p.777</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-a0ecece9b513f2bf397e462036dccffb9c587b8ce1cb3fc21deeb42de451a4e3</citedby><cites>FETCH-LOGICAL-c427t-a0ecece9b513f2bf397e462036dccffb9c587b8ce1cb3fc21deeb42de451a4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154687/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154687/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28489052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Ji-Hyun</creatorcontrib><creatorcontrib>Kim, Kui-Jin</creatorcontrib><creatorcontrib>Lee, Boo-Yong</creatorcontrib><title>Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7 Cells</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>We investigated the beneficial effects of the crude
flake (CEF), which is a residual product after polyphenol extraction from
, on inflammation in LPS-stimulated RAW264.7 cells. A group of five different CEF extracts was obtained by a preparation process using water, hydrochloric acid or temperature. We observed that large-size (>19 kDa) CEF extract, which was extracted with water at 95 °C (CEF-W, 95 °C), suppressed the production of inflammatory cytokines by inhibiting its mRNA expression in LPS-induced RAW264.7 cells. TLR4 signaling involvements were negatively regulated by CEF-W, 95 °C. CEF-W, 95 °C repressed the translocation of NF-κB from cytoplasm into nucleus in LPS-induced RAW264.7 cells. CEF-W, 95 °C attenuated the phosphorylation of TBK1 and IRF3 by inhibiting the phosphorylation of ERK. Taken together, we demonstrated that large-size CEF-W, 95 °C may act as a negative regulator of inflammation through the suppression of TLR4 signaling constituents in LPS-induced RAW264.7 cells.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Attenuation</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - immunology</subject><subject>Cell Nucleus - metabolism</subject><subject>Complex Mixtures - isolation & purification</subject><subject>Complex Mixtures - pharmacology</subject><subject>Cytokines</subject><subject>Cytoplasm</subject><subject>Cytosol - drug effects</subject><subject>Cytosol - immunology</subject><subject>Cytosol - metabolism</subject><subject>Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors</subject><subject>Extracellular Signal-Regulated MAP Kinases - genetics</subject><subject>Extracellular Signal-Regulated MAP Kinases - immunology</subject><subject>Extraction</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Hydrochloric acid</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Interferon regulatory factor 3</subject><subject>Interferon Regulatory Factor-3 - antagonists & inhibitors</subject><subject>Interferon Regulatory Factor-3 - genetics</subject><subject>Interferon Regulatory Factor-3 - immunology</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - antagonists & inhibitors</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mice</subject><subject>NF-kappa B - antagonists & inhibitors</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - immunology</subject><subject>Nuclei (cytology)</subject><subject>Phaeophyceae - chemistry</subject><subject>Phosphorylation</subject><subject>Phosphorylation - drug effects</subject><subject>Protein Serine-Threonine Kinases - antagonists & inhibitors</subject><subject>Protein Serine-Threonine Kinases - genetics</subject><subject>Protein Serine-Threonine Kinases - immunology</subject><subject>Protein Transport</subject><subject>RAW 264.7 Cells</subject><subject>Signal Transduction</subject><subject>Temperature effects</subject><subject>TLR4 protein</subject><subject>Toll-Like Receptor 4 - antagonists & inhibitors</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Toll-Like Receptor 4 - immunology</subject><subject>Toll-like receptors</subject><subject>Translocation</subject><subject>Water scarcity</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkV1rFDEUhoMoba39Ad5IwBtvpuZrPnIjLEurCwuW7YKXQyZzZjZtJqmTpLb_oD_blK2lKrk44eQ5L-fNi9B7Sk45l-Tz5C3oZCEwRkpS1_UrdEQFIwUnQr5-cT9Eb0O4IoRRQcsDdMga0UhSsiP0sJxTD_hMX1vvjMJa3Sp8btV17t3FWekY8CJGcElFwCs3WDVNKhrvcNzNPo27XAFvYEx23_YD3q43Al-a0Slr3IgvVNz9UvfYOLy-uCxWrk8aerxZ_GCVOK3xEqwN79CbQdkAJ0_1GG3Pz7bLb8X6-9fVcrEutGB1LBQBnY_sSsoH1g1c1iAqRnjVaz0MndRlU3eNBqo7PmhGe4BOsB5ESZUAfoy-7GVvUjdBr8Flk7a9mc2k5vvWK9P-_eLMrh39bVvRUlRNnQU-PQnM_meCENvJBJ0dKAc-hZY2UlLSUFJl9OM_6JVPc_6UTGWmlILWjxTdU3r2IcwwPC9DSfsYc_tfzHnmw0sXzxN_cuW_AV57p-U</recordid><startdate>20170510</startdate><enddate>20170510</enddate><creator>Hwang, Ji-Hyun</creator><creator>Kim, Kui-Jin</creator><creator>Lee, Boo-Yong</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170510</creationdate><title>Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7 Cells</title><author>Hwang, Ji-Hyun ; Kim, Kui-Jin ; Lee, Boo-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-a0ecece9b513f2bf397e462036dccffb9c587b8ce1cb3fc21deeb42de451a4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Attenuation</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - immunology</topic><topic>Cell Nucleus - metabolism</topic><topic>Complex Mixtures - isolation & purification</topic><topic>Complex Mixtures - pharmacology</topic><topic>Cytokines</topic><topic>Cytoplasm</topic><topic>Cytosol - drug effects</topic><topic>Cytosol - immunology</topic><topic>Cytosol - metabolism</topic><topic>Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors</topic><topic>Extracellular Signal-Regulated MAP Kinases - genetics</topic><topic>Extracellular Signal-Regulated MAP Kinases - immunology</topic><topic>Extraction</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Hydrochloric acid</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>Interferon regulatory factor 3</topic><topic>Interferon Regulatory Factor-3 - antagonists & inhibitors</topic><topic>Interferon Regulatory Factor-3 - genetics</topic><topic>Interferon Regulatory Factor-3 - immunology</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - antagonists & inhibitors</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Mice</topic><topic>NF-kappa B - antagonists & inhibitors</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - immunology</topic><topic>Nuclei (cytology)</topic><topic>Phaeophyceae - chemistry</topic><topic>Phosphorylation</topic><topic>Phosphorylation - drug effects</topic><topic>Protein Serine-Threonine Kinases - antagonists & inhibitors</topic><topic>Protein Serine-Threonine Kinases - genetics</topic><topic>Protein Serine-Threonine Kinases - immunology</topic><topic>Protein Transport</topic><topic>RAW 264.7 Cells</topic><topic>Signal Transduction</topic><topic>Temperature effects</topic><topic>TLR4 protein</topic><topic>Toll-Like Receptor 4 - antagonists & inhibitors</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Toll-Like Receptor 4 - immunology</topic><topic>Toll-like receptors</topic><topic>Translocation</topic><topic>Water scarcity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Ji-Hyun</creatorcontrib><creatorcontrib>Kim, Kui-Jin</creatorcontrib><creatorcontrib>Lee, Boo-Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Ji-Hyun</au><au>Kim, Kui-Jin</au><au>Lee, Boo-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7 Cells</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2017-05-10</date><risdate>2017</risdate><volume>22</volume><issue>5</issue><spage>777</spage><pages>777-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>We investigated the beneficial effects of the crude
flake (CEF), which is a residual product after polyphenol extraction from
, on inflammation in LPS-stimulated RAW264.7 cells. A group of five different CEF extracts was obtained by a preparation process using water, hydrochloric acid or temperature. We observed that large-size (>19 kDa) CEF extract, which was extracted with water at 95 °C (CEF-W, 95 °C), suppressed the production of inflammatory cytokines by inhibiting its mRNA expression in LPS-induced RAW264.7 cells. TLR4 signaling involvements were negatively regulated by CEF-W, 95 °C. CEF-W, 95 °C repressed the translocation of NF-κB from cytoplasm into nucleus in LPS-induced RAW264.7 cells. CEF-W, 95 °C attenuated the phosphorylation of TBK1 and IRF3 by inhibiting the phosphorylation of ERK. Taken together, we demonstrated that large-size CEF-W, 95 °C may act as a negative regulator of inflammation through the suppression of TLR4 signaling constituents in LPS-induced RAW264.7 cells.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28489052</pmid><doi>10.3390/molecules22050777</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Attenuation Cell Nucleus - drug effects Cell Nucleus - immunology Cell Nucleus - metabolism Complex Mixtures - isolation & purification Complex Mixtures - pharmacology Cytokines Cytoplasm Cytosol - drug effects Cytosol - immunology Cytosol - metabolism Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - immunology Extraction Gene expression Gene Expression Regulation Hydrochloric acid Inflammation Inflammation - prevention & control Interferon regulatory factor 3 Interferon Regulatory Factor-3 - antagonists & inhibitors Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - immunology Lipopolysaccharides Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Mice NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - immunology Nuclei (cytology) Phaeophyceae - chemistry Phosphorylation Phosphorylation - drug effects Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - immunology Protein Transport RAW 264.7 Cells Signal Transduction Temperature effects TLR4 protein Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-like receptors Translocation Water scarcity |
| title | Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7 Cells |
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