Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines

( ), also named cascalote, has been known traditionally in México for having cicatrizing and inflammatory properties. Phytochemical reports on species have identified a high content of phenolic compounds and shown antineoplastic effects against cancer cells. The aim of this study was to isolate and...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-04, Vol.22 (4), p.666
Hauptverfasser:	Sánchez-Carranza, Jessica Nayelli, Alvarez, Laura, Marquina-Bahena, Silvia, Salas-Vidal, Enrique, Cuevas, Verónica, Jiménez, Elizabeth W, Veloz G, Rafael A, Carraz, Maelle, González-Maya, Leticia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bcl-2 protein Caesalpinia - chemistry Caesalpinia coriaria Cancer Caspase Caspase-3 Cell cycle Cell death Cell Proliferation - drug effects Chemical Sciences Cytotoxicity Drug Screening Assays, Antitumor Ethanol Flow cytometry G2 Phase Cell Cycle Checkpoints - drug effects Gallic acid Gallic Acid - analogs & derivatives Gallic Acid - isolation & purification Gallic Acid - pharmacology HeLa Cells Hep G2 Cells Humans Immunofluorescence Inflammation Inhibitory Concentration 50 Life Sciences Medicinal Chemistry Microtubules Microtubules - metabolism Mortality Phenolic compounds Phenols Physical characteristics Phytochemicals Plant Extracts - isolation & purification Plant Extracts - pharmacology Protein Stability Tannic acid Tannins - isolation & purification Tannins - pharmacology Tubulin Modulators - isolation & purification Tubulin Modulators - pharmacology Tumor cell lines
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