Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients—where the cancer only involves the celiac axis—may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2018-10, Vol.22 (10), p.1804-1810 |
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| creator | Klompmaker, Sjors Boggi, Ugo Hackert, Thilo Salvia, Roberto Weiss, Matthew Yamaue, Hiroki Zeh, Herbert J. Besselink, Marc G. |
| description | Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients—where the cancer only involves the celiac axis—may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall survival in selected patients, but it should be reserved for high-volume centers. |
| doi_str_mv | 10.1007/s11605-018-3894-7 |
| format | Article |
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This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. 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| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Celiac Artery - pathology Celiac Artery - surgery Chemotherapy, Adjuvant Fluorouracil - therapeutic use Gastroenterology Gastrointestinal surgery How I do it Humans Irinotecan - therapeutic use Leucovorin - therapeutic use Medicine Medicine & Public Health Neoadjuvant Therapy Neoplasm Staging Oxaliplatin - therapeutic use Pancreatectomy Pancreatectomy - adverse effects Pancreatectomy - methods Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Patient Selection Postoperative Complications - etiology Retrospective Studies Surgery Survival Rate |
| title | Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It |
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