Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population
Background Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non‐melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an assoc...
Gespeichert in:
| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2018-11, Vol.32 (11), p.1893-1896 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1896 |
|---|---|
| container_issue | 11 |
| container_start_page | 1893 |
| container_title | Journal of the European Academy of Dermatology and Venereology |
| container_volume | 32 |
| creator | Ibler, E. Tran, G. Orrell, K.A. Serrano, L. Majewski, S. Sable, K.A. Thiede, R. Laumann, A.E. West, D.P. Nardone, B. |
| description | Background
Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non‐melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD.
Objective
The aim of this study was to determine whether an association exists between MM and AD as well as for NMSC and AD.
Methods
A large urban, Midwestern, US, single‐centre, medical record (EMR) data repository was searched between January 2001 and December 2015, to identify all patients at age ≥60 and |
| doi_str_mv | 10.1111/jdv.14952 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6153078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2018026458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4152-fc2268d02575aa39fbbff2a629ee38cb7e854118023c3c545e554987dbe7b34b3</originalsourceid><addsrcrecordid>eNp1Uctu1DAUtRCIDoUFP4C8A6Sm9SNO4g1SVV5FRSygbC3buZlxSexgJ1OVFZ_A7_A7fAmemTKCBd5c695zzzm6B6HHlBzT_E6u2vUxLaVgd9CCllVTcNLwu2hBJKsKKYU8QA9SuiKEUCqa--iASVHzUtYL9PPcryEmwDqlYJ2eXPC4CxG3Ti99SC7h0OHT_tsK3ADxacqDBDovpNkk-DqDn_AUsAnTCg_Qax8GjbVvsQ_-1_cf-1b64jy22tushvNX417HJRzhORrtj3ByftlD3rCZMeb-e9deQ5ogenz5EY_Z2UZqDOPcb10-RPc63Sd4dFsP0eXrV5_O3hYXH96cn51eFLakghWdZaxqWsJELbTmsjOm65iumATgjTU1NKKktCGMW25FKUCIUjZ1a6A2vDT8EL3Y8Y6zGaDd2tO9GqMbdLxRQTv178S7lVqGtaqo4KRuMsGzW4IY8r3SpAaXLPT5MBDmpBjZqFel2ECf76A2hpQidHsZStQmapWjVtuoM_bJ3772yD_ZZsDJDnDterj5P5N69_LzjvI3nIq6gw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2018026458</pqid></control><display><type>article</type><title>Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Ibler, E. ; Tran, G. ; Orrell, K.A. ; Serrano, L. ; Majewski, S. ; Sable, K.A. ; Thiede, R. ; Laumann, A.E. ; West, D.P. ; Nardone, B.</creator><creatorcontrib>Ibler, E. ; Tran, G. ; Orrell, K.A. ; Serrano, L. ; Majewski, S. ; Sable, K.A. ; Thiede, R. ; Laumann, A.E. ; West, D.P. ; Nardone, B.</creatorcontrib><description>Background
Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non‐melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD.
Objective
The aim of this study was to determine whether an association exists between MM and AD as well as for NMSC and AD.
Methods
A large urban, Midwestern, US, single‐centre, medical record (EMR) data repository was searched between January 2001 and December 2015, to identify all patients at age ≥60 and <89 years with a clinic follow‐up of at least 1 year and no diagnosis for AD, MM or NMSC at the time of the study entry. Data collected included age, gender, race and duration of follow‐up. MM and NMSC were detected by ICD‐9 codes and ICD‐10 codes. Incident diagnosis of AD was also detected by ICD‐9 and ICD‐10 codes. Logistic regression analysis was utilized to obtain crude and adjusted odds ratios (ORs).
Results
Data for a total of 82 925 patients with known race and gender and were detected. After adjusting for confounding factors (race, gender, age, cerebrovascular disease, peripheral vascular disease and diabetes), there was a significant decreased risk of subsequent AD in patients with MM (OR: 0.39; 95% CI: 0.16–0.96; P = 0.042) as well as in patients with BCC (OR: 0.18; 95% CI: 0.08–0.45; P < 0.0001) and for patients with SCC (OR: 0.08; 95% CI: 0.01–0.56; P = 0.013).
Conclusion
These findings add to the growing body of evidence for a decreased risk of AD in patients with various cancers and highlight the need for ongoing research to elucidate both neurologic and biologic mechanisms that may underlie this apparent inverse association.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.14952</identifier><identifier>PMID: 29573497</identifier><language>eng</language><publisher>England</publisher><subject>Academic Medical Centers ; Age Distribution ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - epidemiology ; Carcinoma, Basal Cell - epidemiology ; Carcinoma, Basal Cell - pathology ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Comorbidity ; Confidence Intervals ; Databases, Factual ; Female ; Humans ; Logistic Models ; Male ; Melanoma - diagnosis ; Melanoma - epidemiology ; Melanoma, Cutaneous Malignant ; Middle Aged ; Midwestern United States - epidemiology ; Multivariate Analysis ; Prevalence ; Prognosis ; Retrospective Studies ; Sex Distribution ; Skin Neoplasms - diagnosis ; Skin Neoplasms - epidemiology ; Skin Neoplasms - pathology</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2018-11, Vol.32 (11), p.1893-1896</ispartof><rights>2018 European Academy of Dermatology and Venereology</rights><rights>2018 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4152-fc2268d02575aa39fbbff2a629ee38cb7e854118023c3c545e554987dbe7b34b3</citedby><cites>FETCH-LOGICAL-c4152-fc2268d02575aa39fbbff2a629ee38cb7e854118023c3c545e554987dbe7b34b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.14952$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.14952$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29573497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibler, E.</creatorcontrib><creatorcontrib>Tran, G.</creatorcontrib><creatorcontrib>Orrell, K.A.</creatorcontrib><creatorcontrib>Serrano, L.</creatorcontrib><creatorcontrib>Majewski, S.</creatorcontrib><creatorcontrib>Sable, K.A.</creatorcontrib><creatorcontrib>Thiede, R.</creatorcontrib><creatorcontrib>Laumann, A.E.</creatorcontrib><creatorcontrib>West, D.P.</creatorcontrib><creatorcontrib>Nardone, B.</creatorcontrib><title>Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non‐melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD.
Objective
The aim of this study was to determine whether an association exists between MM and AD as well as for NMSC and AD.
Methods
A large urban, Midwestern, US, single‐centre, medical record (EMR) data repository was searched between January 2001 and December 2015, to identify all patients at age ≥60 and <89 years with a clinic follow‐up of at least 1 year and no diagnosis for AD, MM or NMSC at the time of the study entry. Data collected included age, gender, race and duration of follow‐up. MM and NMSC were detected by ICD‐9 codes and ICD‐10 codes. Incident diagnosis of AD was also detected by ICD‐9 and ICD‐10 codes. Logistic regression analysis was utilized to obtain crude and adjusted odds ratios (ORs).
Results
Data for a total of 82 925 patients with known race and gender and were detected. After adjusting for confounding factors (race, gender, age, cerebrovascular disease, peripheral vascular disease and diabetes), there was a significant decreased risk of subsequent AD in patients with MM (OR: 0.39; 95% CI: 0.16–0.96; P = 0.042) as well as in patients with BCC (OR: 0.18; 95% CI: 0.08–0.45; P < 0.0001) and for patients with SCC (OR: 0.08; 95% CI: 0.01–0.56; P = 0.013).
Conclusion
These findings add to the growing body of evidence for a decreased risk of AD in patients with various cancers and highlight the need for ongoing research to elucidate both neurologic and biologic mechanisms that may underlie this apparent inverse association.</description><subject>Academic Medical Centers</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Carcinoma, Basal Cell - epidemiology</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Comorbidity</subject><subject>Confidence Intervals</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - epidemiology</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Middle Aged</subject><subject>Midwestern United States - epidemiology</subject><subject>Multivariate Analysis</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sex Distribution</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - pathology</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uctu1DAUtRCIDoUFP4C8A6Sm9SNO4g1SVV5FRSygbC3buZlxSexgJ1OVFZ_A7_A7fAmemTKCBd5c695zzzm6B6HHlBzT_E6u2vUxLaVgd9CCllVTcNLwu2hBJKsKKYU8QA9SuiKEUCqa--iASVHzUtYL9PPcryEmwDqlYJ2eXPC4CxG3Ti99SC7h0OHT_tsK3ADxacqDBDovpNkk-DqDn_AUsAnTCg_Qax8GjbVvsQ_-1_cf-1b64jy22tushvNX417HJRzhORrtj3ByftlD3rCZMeb-e9deQ5ogenz5EY_Z2UZqDOPcb10-RPc63Sd4dFsP0eXrV5_O3hYXH96cn51eFLakghWdZaxqWsJELbTmsjOm65iumATgjTU1NKKktCGMW25FKUCIUjZ1a6A2vDT8EL3Y8Y6zGaDd2tO9GqMbdLxRQTv178S7lVqGtaqo4KRuMsGzW4IY8r3SpAaXLPT5MBDmpBjZqFel2ECf76A2hpQidHsZStQmapWjVtuoM_bJ3772yD_ZZsDJDnDterj5P5N69_LzjvI3nIq6gw</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Ibler, E.</creator><creator>Tran, G.</creator><creator>Orrell, K.A.</creator><creator>Serrano, L.</creator><creator>Majewski, S.</creator><creator>Sable, K.A.</creator><creator>Thiede, R.</creator><creator>Laumann, A.E.</creator><creator>West, D.P.</creator><creator>Nardone, B.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201811</creationdate><title>Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population</title><author>Ibler, E. ; Tran, G. ; Orrell, K.A. ; Serrano, L. ; Majewski, S. ; Sable, K.A. ; Thiede, R. ; Laumann, A.E. ; West, D.P. ; Nardone, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-fc2268d02575aa39fbbff2a629ee38cb7e854118023c3c545e554987dbe7b34b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Academic Medical Centers</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Carcinoma, Basal Cell - epidemiology</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Comorbidity</topic><topic>Confidence Intervals</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - epidemiology</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Middle Aged</topic><topic>Midwestern United States - epidemiology</topic><topic>Multivariate Analysis</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sex Distribution</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibler, E.</creatorcontrib><creatorcontrib>Tran, G.</creatorcontrib><creatorcontrib>Orrell, K.A.</creatorcontrib><creatorcontrib>Serrano, L.</creatorcontrib><creatorcontrib>Majewski, S.</creatorcontrib><creatorcontrib>Sable, K.A.</creatorcontrib><creatorcontrib>Thiede, R.</creatorcontrib><creatorcontrib>Laumann, A.E.</creatorcontrib><creatorcontrib>West, D.P.</creatorcontrib><creatorcontrib>Nardone, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibler, E.</au><au>Tran, G.</au><au>Orrell, K.A.</au><au>Serrano, L.</au><au>Majewski, S.</au><au>Sable, K.A.</au><au>Thiede, R.</au><au>Laumann, A.E.</au><au>West, D.P.</au><au>Nardone, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2018-11</date><risdate>2018</risdate><volume>32</volume><issue>11</issue><spage>1893</spage><epage>1896</epage><pages>1893-1896</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non‐melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD.
Objective
The aim of this study was to determine whether an association exists between MM and AD as well as for NMSC and AD.
Methods
A large urban, Midwestern, US, single‐centre, medical record (EMR) data repository was searched between January 2001 and December 2015, to identify all patients at age ≥60 and <89 years with a clinic follow‐up of at least 1 year and no diagnosis for AD, MM or NMSC at the time of the study entry. Data collected included age, gender, race and duration of follow‐up. MM and NMSC were detected by ICD‐9 codes and ICD‐10 codes. Incident diagnosis of AD was also detected by ICD‐9 and ICD‐10 codes. Logistic regression analysis was utilized to obtain crude and adjusted odds ratios (ORs).
Results
Data for a total of 82 925 patients with known race and gender and were detected. After adjusting for confounding factors (race, gender, age, cerebrovascular disease, peripheral vascular disease and diabetes), there was a significant decreased risk of subsequent AD in patients with MM (OR: 0.39; 95% CI: 0.16–0.96; P = 0.042) as well as in patients with BCC (OR: 0.18; 95% CI: 0.08–0.45; P < 0.0001) and for patients with SCC (OR: 0.08; 95% CI: 0.01–0.56; P = 0.013).
Conclusion
These findings add to the growing body of evidence for a decreased risk of AD in patients with various cancers and highlight the need for ongoing research to elucidate both neurologic and biologic mechanisms that may underlie this apparent inverse association.</abstract><cop>England</cop><pmid>29573497</pmid><doi>10.1111/jdv.14952</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0926-9959 |
| ispartof | Journal of the European Academy of Dermatology and Venereology, 2018-11, Vol.32 (11), p.1893-1896 |
| issn | 0926-9959 1468-3083 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6153078 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Academic Medical Centers Age Distribution Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Carcinoma, Basal Cell - epidemiology Carcinoma, Basal Cell - pathology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Comorbidity Confidence Intervals Databases, Factual Female Humans Logistic Models Male Melanoma - diagnosis Melanoma - epidemiology Melanoma, Cutaneous Malignant Middle Aged Midwestern United States - epidemiology Multivariate Analysis Prevalence Prognosis Retrospective Studies Sex Distribution Skin Neoplasms - diagnosis Skin Neoplasms - epidemiology Skin Neoplasms - pathology |
| title | Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T11%3A56%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inverse%20association%20for%20diagnosis%20of%20Alzheimer's%20disease%20subsequent%20to%20both%20melanoma%20and%20non%E2%80%90melanoma%20skin%20cancers%20in%20a%20large,%20urban,%20single%E2%80%90centre,%20Midwestern%20US%20patient%20population&rft.jtitle=Journal%20of%20the%20European%20Academy%20of%20Dermatology%20and%20Venereology&rft.au=Ibler,%20E.&rft.date=2018-11&rft.volume=32&rft.issue=11&rft.spage=1893&rft.epage=1896&rft.pages=1893-1896&rft.issn=0926-9959&rft.eissn=1468-3083&rft_id=info:doi/10.1111/jdv.14952&rft_dat=%3Cproquest_pubme%3E2018026458%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2018026458&rft_id=info:pmid/29573497&rfr_iscdi=true |