Cholinesterase Inhibitory Activities of Adamantyl-Based Derivatives and Their Molecular Docking Studies

Adamantyl-based compounds are clinically important for the treatments of type 2 diabetes and for their antiviral abilities, while many more are under development for other pharmaceutical uses. This study focused on the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activitie...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-06, Vol.22 (6), p.1005
Hauptverfasser:	Kwong, Huey Chong, Mah, Siau Hui, Chia, Tze Shyang, Quah, Ching Kheng, Lim, Gin Keat, Kumar, C S Chidan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - chemistry Binding Sites Catalytic Domain Chemical bonds Cholinesterase Cholinesterase inhibitors Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Colorimetry Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dose-Response Relationship, Drug Hydrogen bonding Hydrogen bonds Hydrophobicity Inhibition Inhibitory Concentration 50 Isomers Molecular Conformation Molecular docking Molecular Docking Simulation Molecular Dynamics Simulation Nitrogen dioxide Protein Binding Proteins Structure-Activity Relationship
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