Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains

The focus of this study is the expression of Toll-like receptor-3 (TLR-3), a receptor for double-stranded RNA, in human brains affected by Alzheimer's disease (AD) pathology. Toll-like receptors are a family of pattern recognition molecules primarily involved in host defenses to microbial patho...

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Veröffentlicht in:	Experimental neurology 2018-11, Vol.309, p.91-106
Hauptverfasser:	Walker, Douglas G., Tang, Tiffany M., Lue, Lih-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Brain - metabolism Brain - pathology Calcium-Binding Proteins Case-Control Studies Cells, Cultured Cytokines - metabolism DNA-Binding Proteins - metabolism Endothelial Cells - drug effects Gene Expression - drug effects Gene Expression - physiology HEK293 Cells Humans Immunohistochemistry Inflammation Interferon responses Microfilament Proteins Microglia Microglia - metabolism Microglia - pathology Neuroglia - metabolism Neuroglia - pathology Neuropathology Peptide Fragments - pharmacology Phagocytosis Phosphopyruvate Hydratase - metabolism Plaques Poly I-C - pharmacology RNA-Binding Proteins - metabolism Tangles Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Toll-Like Receptors - genetics Toll-Like Receptors - metabolism
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