Induced Adult Neurogenesis plus BDNF Mimicks the Effects of Exercise on Cognition in an Alzheimer’s Mouse Model
Adult hippocampal neurogenesis (AHN) is impaired prior to the onset of Alzheimer’s disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AH...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2018-09, Vol.361 (6406) |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 361 |
| creator | Choi, Se Hoon Bylykbashi, Enjana Chatila, Zena K. Lee, Star W. Pulli, Benjamin Clemenson, Gregory D. Kim, Eunhee Rompala, Alexander Oram, Mary K. Asselin, Caroline Aronson, Jenna Zhang, Can Miller, Sean J. Lesinski, Andrea Chen, John W. Kim, Doo Yeon van Praag, Henriette Spiegelman, Bruce M. Gage, Fred H. Tanzi, Rudolph E. |
| description | Adult hippocampal neurogenesis (AHN) is impaired prior to the onset of Alzheimer’s disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased AHN, ameliorated cognition. We successfully mimicked the beneficial effects of exercise on AD mice by genetically and pharmacologically inducing AHN in combination with elevating BDNF levels. Suppressing AHN later led to worsened cognitive performance and loss of pre-existing dentate neurons. Thus, pharmacological mimetics of exercise, enhancing AHN and elevating BDNF levels, may improve cognition in AD. Furthermore, applied at early stages of AD, these mimetics may protect against subsequent neuronal cell death.
Role of Adult Neurogenesis in Alzheimer’s Disease. |
| doi_str_mv | 10.1126/science.aan8821 |
| format | Article |
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We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased AHN, ameliorated cognition. We successfully mimicked the beneficial effects of exercise on AD mice by genetically and pharmacologically inducing AHN in combination with elevating BDNF levels. Suppressing AHN later led to worsened cognitive performance and loss of pre-existing dentate neurons. Thus, pharmacological mimetics of exercise, enhancing AHN and elevating BDNF levels, may improve cognition in AD. Furthermore, applied at early stages of AD, these mimetics may protect against subsequent neuronal cell death.
Role of Adult Neurogenesis in Alzheimer’s Disease.</abstract><pmid>30190379</pmid><doi>10.1126/science.aan8821</doi></addata></record> |
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| title | Induced Adult Neurogenesis plus BDNF Mimicks the Effects of Exercise on Cognition in an Alzheimer’s Mouse Model |
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