A novel mechanism of plasminogen activation in epithelial and mesenchymal cells

Cancer dissemination is initiated by the movement of cells into the vasculature which has been reported to be triggered by EMT (epithelial to mesenchymal transition). Cellular dissemination also requires proteases that remodel the extracellular matrix. The protease, plasmin is a prominent player in...

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Veröffentlicht in:	Scientific reports 2018-09, Vol.8 (1), p.14091, Article 14091
Hauptverfasser:	Bydoun, Moamen, Sterea, Andra, Weaver, Ian C. G., Bharadwaj, Alamelu G., Waisman, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/1 13/106 13/109 13/31 13/95 38/77 42/89 631/45/468 631/67/1612/1350 Annexin A2 - metabolism Calcium-binding protein Cancer Cell activation Cell Line Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - physiology Extracellular matrix Fibrinolysin - metabolism Humanities and Social Sciences Humans Kinases Mesenchyme Metastasis Morphology multidisciplinary Phosphatidylinositol 3-Kinases - metabolism Physiology Plasmin Plasminogen - metabolism Plasminogen Activator Inhibitor 1 - metabolism Plasminogen activator inhibitors Protein expression Proteins S100 protein S100 Proteins - metabolism Science Science (multidisciplinary) Signal Transduction - physiology Smad protein Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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