Optogenetic control of epithelial-mesenchymal transition in cancer cells

Epithelial-mesenchymal transition (EMT) is one of the most important mechanisms in the initiation and promotion of cancer cell metastasis. The phosphoinositide 3-kinase (PI3K) signaling pathway has been demonstrated to be involved in TGF-β induced EMT, but the complicated TGF-β signaling network mak...

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Veröffentlicht in:	Scientific reports 2018-09, Vol.8 (1), p.14098-9, Article 14098
Hauptverfasser:	Zhou, Xiaoxu, Wang, Jian, Chen, Junye, Qi, Yuankai, Di Nan, Jin, Luhong, Qian, Xiaohan, Wang, Xinyi, Chen, Qingyong, Liu, Xu, Xu, Yingke
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/106 13/109 13/95 14/35 14/63 631/1647/2253 631/80/304 Cancer Cell adhesion & migration Cell migration Cell Movement - drug effects E-cadherin Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Genetics HeLa Cells Humanities and Social Sciences Humans Information processing Kinases Mesenchyme Metastases multidisciplinary Optics Optogenetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transforming Growth Factor beta - pharmacology
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