Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents

This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K 2 [PtCl 4 ] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2002-04, Vol.7 (4), p.405-411
Hauptverfasser:	de Almeida, Mauro Vieira, Fontes, Ana Paula Soares, Berg, Richard Nilton, César, Eloi Teixeira, de Castro Antunes Felício, Emanoel, de Souza Filho, José Dias
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K 2 [PtCl 4 ] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.
ISSN:	1420-3049
DOI:	10.3390/70400405