Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by progressive decline in pulmonary function and ultimately respiratory failure. Genetic and environmental risk factors have been identified that indicate injury to, and dysfunction of the lung epithelium is...

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Veröffentlicht in:	Matrix biology 2018-10, Vol.71-72, p.112-127
Hauptverfasser:	Hewlett, Justin C., Kropski, Jonathan A., Blackwell, Timothy S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial-Mesenchymal Transition - drug effects Epithelium Extracellular matrix Extracellular Matrix - metabolism Fibrosis Genetics Growth factors Humans Idiopathic Pulmonary Fibrosis - drug therapy Idiopathic Pulmonary Fibrosis - etiology Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - physiopathology Inflammation Interstitial lung disease IPF Lung - metabolism Lung - physiopathology Lung diseases Matrix Mechanical properties Mesenchyme Molecular Targeted Therapy Pulmonary fibrosis Respiratory function Risk factors Signal Transduction Therapeutic applications Treatment
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