Comprehensive Single-Shot Proteomics with FAIMS on a Hybrid Orbitrap Mass Spectrometer

Liquid chromatography (LC) prefractionation is often implemented to increase proteomic coverage; however, while effective, this approach is laborious, requires considerable sample amount, and can be cumbersome. We describe how interfacing a recently described high-field asymmetric waveform ion mobil...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-08, Vol.90 (15), p.9529-9537
Hauptverfasser:	Hebert, Alexander S, Prasad, Satendra, Belford, Michael W, Bailey, Derek J, McAlister, Graeme C, Abbatiello, Susan E, Huguet, Romain, Wouters, Eloy R, Dunyach, Jean-Jacques, Brademan, Dain R, Westphall, Michael S, Coon, Joshua J
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry electric field Electric field strength electric power Emitters Fractionation gases Helium human cell lines INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Ion transport Ionic mobility Ionization Liquid chromatography Mass spectrometry Phase transitions Proteins Proteomics Shot spectrometers spectroscopy Waveform analysis
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