Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

Nonsense-mediated mRNA decay (NMD) is responsible for the degradation of mRNAs with a premature termination codon (PTC). The role of this system in cancer is still quite poorly understood. In the present study, we evaluated the functional consequences of NMD activity in a subgroup of colorectal canc...

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Veröffentlicht in:	Oncogenesis (New York, NY) NY), 2018-09, Vol.7 (9), p.70-9, Article 70
Hauptverfasser:	Bokhari, A’dem, Jonchere, Vincent, Lagrange, Anaïs, Bertrand, Romane, Svrcek, Magali, Marisa, Laetitia, Buhard, Olivier, Greene, Malorie, Demidova, Anastasia, Jia, Jieshuang, Adriaenssens, Eric, Chassat, Thierry, Biard, Denis S., Flejou, Jean-François, Lejeune, Fabrice, Duval, Alex, Collura, Ada
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/89 38/39 38/79 38/90 45/77 631/67/1504 631/67/68 Apoptosis Cancer Cell Biology Colorectal cancer Human Genetics Internal Medicine Life Sciences Medicine Medicine & Public Health Microsatellite instability mRNA turnover Nonsense mutation Nonsense-mediated mRNA decay Oncology Tumorigenesis
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