Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

•Report of a Phase I clinical trial to assess a malaria transmission blocking vaccine.•P. falciparum Pfs25 virus-like particle produced under cGMP in a plant-based system.•The vaccine candidate displays an acceptable safety and tolerability profile.•The vaccine candidate induced Pfs25-specific IgG i...

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Veröffentlicht in:	Vaccine 2018-09, Vol.36 (39), p.5865-5871
Hauptverfasser:	Chichester, Jessica A., Green, Brian J., Jones, R. Mark, Shoji, Yoko, Miura, Kazutoyo, Long, Carole A., Lee, Cynthia K., Ockenhouse, Christian F., Morin, Merribeth J., Streatfield, Stephen J., Yusibov, Vidadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adolescent Adult Adults Alfalfa Alfalfa mosaic virus Antibodies Antibodies, Protozoan - blood Antigens Antigens, Protozoan - immunology Aquatic insects Coat protein coat proteins Culicidae Disease spread Disease transmission dose response Drug dosages Family medical history Female Gametes germ cells good manufacturing practices guidelines Healthy Volunteers Hispanic Americans Humans Immunogenicity Immunogenicity, Vaccine Immunoglobulin G Malaria malaria vaccines Malaria Vaccines - adverse effects Malaria Vaccines - immunology Malaria, Falciparum - prevention & control Male Middle Aged Midgut Mosquitoes Nicotiana - metabolism Nicotiana benthamiana ookinetes Parasites patients Pfs25 Plant virus diseases Plant viruses Plant-produced Plants Plasmodium falciparum Proteins Protozoan Proteins - immunology Safety Sexual stages Toxicity Transmission blocking vaccine tropical diseases vaccine adjuvants Vaccines Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Vaccines, Virus-Like Particle - immunology Vector-borne diseases Virus-like particle Virus-like particles Viruses volunteers Young Adult zygote Zygotes
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