Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

The limited host tropism of numerous viruses causing disease in humans remains incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has reemerged in recent years. Here, we demonstrate that ZIKV efficiently infects fibroblasts from humans, great apes, New and Old World monkeys...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-07, Vol.115 (27), p.E6310-E6318
Hauptverfasser:	Ding, Qiang, Gaska, Jenna M., Douam, Florian, Wei, Lei, Kim, David, Balev, Metodi, Heller, Brigitte, Ploss, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral drugs Apes Biodiversity Biological Sciences Chlorocebus aethiops Cleavage Cyclic GMP Dengue fever Disease control Disruption Encephalitis Fever Fibroblasts HEK293 Cells Host range Humans Immunity, Innate Infections Interferon Membrane Proteins - genetics Membrane Proteins - immunology Mice Monkeys Peptide Hydrolases - genetics Peptide Hydrolases - immunology Permissivity Phenotypes PNAS Plus Primates Protease Proteases Proteinase Proteolysis Ribonucleic acid RNA RNA viruses Rodents Signal transduction Signal Transduction - genetics Signal Transduction - immunology Signaling Species Specificity Stimulators Tropism Vector-borne diseases Vero Cells Viral diseases Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viruses West Nile virus Zika virus Zika Virus - genetics Zika Virus - immunology
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