Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma

Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high v...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-07, Vol.115 (27), p.E6283-E6290
Hauptverfasser:	Gopal, Raj K., Calvo, Sarah E., Shih, Angela R., Chaves, Frances L., McGuone, Declan, Mick, Eran, Pierce, Kerry A., Li, Yang, Garofalo, Andrea, Van Allen, Eliezer M., Clish, Clary B., Oliva, Esther, Mootha, Vamsi K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Oxyphilic - genetics Adenoma, Oxyphilic - metabolism Adenoma, Oxyphilic - pathology Biological Sciences Cell Survival - genetics Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 1 - metabolism Cyclin D1 - genetics Cyclin D1 - metabolism DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Electron Transport Complex I - deficiency Female Gene Expression Profiling Glutathione - genetics Glutathione - metabolism Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Neoplasm Proteins - deficiency PNAS Plus
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