Neuraminidase as an influenza vaccine antigen: a low hanging fruit, ready for picking to improve vaccine effectiveness

[Display omitted] •Neuraminidase (NA)-inhibiting antibodies are an independent correlate of vaccine efficacy.•Many NA-specific antibodies bind to conserved epitopes and protect against heterologous viruses.•Assays to measure NA content and immunogenicity of influenza vaccines have been developed. Ne...

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Veröffentlicht in:	Current opinion in immunology 2018-08, Vol.53, p.38-44
Hauptverfasser:	Eichelberger, Maryna C, Morens, David M, Taubenberger, Jeffery K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - metabolism Conserved Sequence - genetics Humans Immunity, Heterologous Influenza A virus - immunology Influenza Vaccines - immunology Influenza, Human - immunology Neuraminidase - genetics Neuraminidase - immunology Orthomyxoviridae Infections - immunology
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