Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
ABSTRACT BACKGROUND Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS From the Canadian Healthy Infa...
Gespeichert in:
| Veröffentlicht in: | Canadian Medical Association journal (CMAJ) 2018-09, Vol.190 (37), p.E1097-E1107 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | E1107 |
|---|---|
| container_issue | 37 |
| container_start_page | E1097 |
| container_title | Canadian Medical Association journal (CMAJ) |
| container_volume | 190 |
| creator | Tun, Mon H., MBBS MSc Kozyrskyj, Anita L., PhD Tun, Hein M., DVM PhD Mahoney, Justin J., MSc Mandhane, Piush J., MD PhD Konya, Theodore B., MSc Brook, Jeffrey R., PhD Lou, Wendy, PhD Scott, James A., PhD Guttman, David S., PhD Becker, Allan B., MD Turvey, Stuart E., MBBS DPhil Subbarao, Padmaja, MD MSc Sears, Malcolm R., MBChB Takarao, Tim K., MD MSc |
| description | ABSTRACT BACKGROUND Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score ( p = 0.02) and with increased odds of overweight or obesity ( p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation ( p = 0.2). INTERPRETATION Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association. |
| doi_str_mv | 10.1503/cmaj.170809 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6141245</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A554494010</galeid><els_id>1_s2_0_S0820394618307132</els_id><sourcerecordid>A554494010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c761t-bae2a0c39195291dadb6ea3cb7152a0dca1fec84c18317a48232eac8ee44c23f3</originalsourceid><addsrcrecordid>eNqVk9tv0zAUxiMEYmXwxDuKmIRAkOJbmuQFaZq4TJoAMXi2HOckcefGne2U7b_nVB1di_pC8hAr5-fP5_I5SZ5TMqU54e_1Qs2ntCAlqR4kEyrKMmOcVQ-TCSkZyXglZkfJkxDmBB_OisfJESeMCSHYJPHfXYiDisqmcLN0YfSQRpf2bgzQO9ukjQlmaEFHNcTwLsU1LtJujOnCaO9q46JK1dCkYawDXI-AUW_CVera1K3A_wbT9RH3pbo3tvEwPE0etcoGeHb3PU5-ffr48-xLdvHt8_nZ6UWmixmNWa2AKaJ5RaucVbRRTT0DxXVd0BwDjVYU0yqFpiWnhRIlFg1KlwBCaMZbfpx82Ogux3oBjcbMvLJy6c1C-VvplJH7kcH0snMrOaOCMpGjwOs7Ae-wsBDlwgQN1qoBsD-SUVJx7HRRIXryDzp3ox-wPKRoyWZlnuf3VKcsSGylw3P1WlSe5rkQlSCUIJUdoDoYAJN0A7QGf-_xLw_wemmu5S40PQDh2wDO8aDqm70NyES4iZ0aQ5Dnlz_-g_26z77aYXtQNvbB2TEaN4R98O0GRJeF4KHdTo4SuTa-XBtfboyP9IvdYW_Zv06_dwOg5VYGvNTWDEYrewW3ELbjojIwSeTl-u6srw66ixSUM_4HwAsQzg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2118268555</pqid></control><display><type>article</type><title>Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Tun, Mon H., MBBS MSc ; Kozyrskyj, Anita L., PhD ; Tun, Hein M., DVM PhD ; Mahoney, Justin J., MSc ; Mandhane, Piush J., MD PhD ; Konya, Theodore B., MSc ; Brook, Jeffrey R., PhD ; Lou, Wendy, PhD ; Scott, James A., PhD ; Guttman, David S., PhD ; Becker, Allan B., MD ; Turvey, Stuart E., MBBS DPhil ; Subbarao, Padmaja, MD MSc ; Sears, Malcolm R., MBChB ; Takarao, Tim K., MD MSc</creator><creatorcontrib>Tun, Mon H., MBBS MSc ; Kozyrskyj, Anita L., PhD ; Tun, Hein M., DVM PhD ; Mahoney, Justin J., MSc ; Mandhane, Piush J., MD PhD ; Konya, Theodore B., MSc ; Brook, Jeffrey R., PhD ; Lou, Wendy, PhD ; Scott, James A., PhD ; Guttman, David S., PhD ; Becker, Allan B., MD ; Turvey, Stuart E., MBBS DPhil ; Subbarao, Padmaja, MD MSc ; Sears, Malcolm R., MBChB ; Takarao, Tim K., MD MSc ; CHILD Study Investigators</creatorcontrib><description>ABSTRACT BACKGROUND Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score ( p = 0.02) and with increased odds of overweight or obesity ( p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation ( p = 0.2). INTERPRETATION Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.</description><identifier>ISSN: 0820-3946</identifier><identifier>EISSN: 1488-2329</identifier><identifier>DOI: 10.1503/cmaj.170809</identifier><identifier>PMID: 30224442</identifier><language>eng</language><publisher>Canada: Joule Inc</publisher><subject>Age ; Babies ; Births ; Child development ; Childhood obesity ; Children & youth ; Cleaning agents ; Evaluation ; Feces ; Green products ; Health care ; Households ; Internal Medicine ; Mediation ; Metabolism ; Metabolites ; Microbiota ; Microbiota (Symbiotic organisms) ; Obesity ; Overweight ; Risk factors ; Streptococcus infections</subject><ispartof>Canadian Medical Association journal (CMAJ), 2018-09, Vol.190 (37), p.E1097-E1107</ispartof><rights>Joule Inc. or its licensors</rights><rights>2018 Joule Inc. or its licensors.</rights><rights>COPYRIGHT 2018 Joule Inc.</rights><rights>Copyright Joule Inc Sep 17, 2018</rights><rights>2018 Joule Inc. or its licensors 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c761t-bae2a0c39195291dadb6ea3cb7152a0dca1fec84c18317a48232eac8ee44c23f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141245/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141245/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30224442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tun, Mon H., MBBS MSc</creatorcontrib><creatorcontrib>Kozyrskyj, Anita L., PhD</creatorcontrib><creatorcontrib>Tun, Hein M., DVM PhD</creatorcontrib><creatorcontrib>Mahoney, Justin J., MSc</creatorcontrib><creatorcontrib>Mandhane, Piush J., MD PhD</creatorcontrib><creatorcontrib>Konya, Theodore B., MSc</creatorcontrib><creatorcontrib>Brook, Jeffrey R., PhD</creatorcontrib><creatorcontrib>Lou, Wendy, PhD</creatorcontrib><creatorcontrib>Scott, James A., PhD</creatorcontrib><creatorcontrib>Guttman, David S., PhD</creatorcontrib><creatorcontrib>Becker, Allan B., MD</creatorcontrib><creatorcontrib>Turvey, Stuart E., MBBS DPhil</creatorcontrib><creatorcontrib>Subbarao, Padmaja, MD MSc</creatorcontrib><creatorcontrib>Sears, Malcolm R., MBChB</creatorcontrib><creatorcontrib>Takarao, Tim K., MD MSc</creatorcontrib><creatorcontrib>CHILD Study Investigators</creatorcontrib><title>Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children</title><title>Canadian Medical Association journal (CMAJ)</title><addtitle>CMAJ</addtitle><description>ABSTRACT BACKGROUND Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score ( p = 0.02) and with increased odds of overweight or obesity ( p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation ( p = 0.2). INTERPRETATION Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.</description><subject>Age</subject><subject>Babies</subject><subject>Births</subject><subject>Child development</subject><subject>Childhood obesity</subject><subject>Children & youth</subject><subject>Cleaning agents</subject><subject>Evaluation</subject><subject>Feces</subject><subject>Green products</subject><subject>Health care</subject><subject>Households</subject><subject>Internal Medicine</subject><subject>Mediation</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Risk factors</subject><subject>Streptococcus infections</subject><issn>0820-3946</issn><issn>1488-2329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVk9tv0zAUxiMEYmXwxDuKmIRAkOJbmuQFaZq4TJoAMXi2HOckcefGne2U7b_nVB1di_pC8hAr5-fP5_I5SZ5TMqU54e_1Qs2ntCAlqR4kEyrKMmOcVQ-TCSkZyXglZkfJkxDmBB_OisfJESeMCSHYJPHfXYiDisqmcLN0YfSQRpf2bgzQO9ukjQlmaEFHNcTwLsU1LtJujOnCaO9q46JK1dCkYawDXI-AUW_CVera1K3A_wbT9RH3pbo3tvEwPE0etcoGeHb3PU5-ffr48-xLdvHt8_nZ6UWmixmNWa2AKaJ5RaucVbRRTT0DxXVd0BwDjVYU0yqFpiWnhRIlFg1KlwBCaMZbfpx82Ogux3oBjcbMvLJy6c1C-VvplJH7kcH0snMrOaOCMpGjwOs7Ae-wsBDlwgQN1qoBsD-SUVJx7HRRIXryDzp3ox-wPKRoyWZlnuf3VKcsSGylw3P1WlSe5rkQlSCUIJUdoDoYAJN0A7QGf-_xLw_wemmu5S40PQDh2wDO8aDqm70NyES4iZ0aQ5Dnlz_-g_26z77aYXtQNvbB2TEaN4R98O0GRJeF4KHdTo4SuTa-XBtfboyP9IvdYW_Zv06_dwOg5VYGvNTWDEYrewW3ELbjojIwSeTl-u6srw66ixSUM_4HwAsQzg</recordid><startdate>20180917</startdate><enddate>20180917</enddate><creator>Tun, Mon H., MBBS MSc</creator><creator>Kozyrskyj, Anita L., PhD</creator><creator>Tun, Hein M., DVM PhD</creator><creator>Mahoney, Justin J., MSc</creator><creator>Mandhane, Piush J., MD PhD</creator><creator>Konya, Theodore B., MSc</creator><creator>Brook, Jeffrey R., PhD</creator><creator>Lou, Wendy, PhD</creator><creator>Scott, James A., PhD</creator><creator>Guttman, David S., PhD</creator><creator>Becker, Allan B., MD</creator><creator>Turvey, Stuart E., MBBS DPhil</creator><creator>Subbarao, Padmaja, MD MSc</creator><creator>Sears, Malcolm R., MBChB</creator><creator>Takarao, Tim K., MD MSc</creator><general>Joule Inc</general><general>CMA Impact, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180917</creationdate><title>Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children</title><author>Tun, Mon H., MBBS MSc ; Kozyrskyj, Anita L., PhD ; Tun, Hein M., DVM PhD ; Mahoney, Justin J., MSc ; Mandhane, Piush J., MD PhD ; Konya, Theodore B., MSc ; Brook, Jeffrey R., PhD ; Lou, Wendy, PhD ; Scott, James A., PhD ; Guttman, David S., PhD ; Becker, Allan B., MD ; Turvey, Stuart E., MBBS DPhil ; Subbarao, Padmaja, MD MSc ; Sears, Malcolm R., MBChB ; Takarao, Tim K., MD MSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c761t-bae2a0c39195291dadb6ea3cb7152a0dca1fec84c18317a48232eac8ee44c23f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Babies</topic><topic>Births</topic><topic>Child development</topic><topic>Childhood obesity</topic><topic>Children & youth</topic><topic>Cleaning agents</topic><topic>Evaluation</topic><topic>Feces</topic><topic>Green products</topic><topic>Health care</topic><topic>Households</topic><topic>Internal Medicine</topic><topic>Mediation</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Risk factors</topic><topic>Streptococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tun, Mon H., MBBS MSc</creatorcontrib><creatorcontrib>Kozyrskyj, Anita L., PhD</creatorcontrib><creatorcontrib>Tun, Hein M., DVM PhD</creatorcontrib><creatorcontrib>Mahoney, Justin J., MSc</creatorcontrib><creatorcontrib>Mandhane, Piush J., MD PhD</creatorcontrib><creatorcontrib>Konya, Theodore B., MSc</creatorcontrib><creatorcontrib>Brook, Jeffrey R., PhD</creatorcontrib><creatorcontrib>Lou, Wendy, PhD</creatorcontrib><creatorcontrib>Scott, James A., PhD</creatorcontrib><creatorcontrib>Guttman, David S., PhD</creatorcontrib><creatorcontrib>Becker, Allan B., MD</creatorcontrib><creatorcontrib>Turvey, Stuart E., MBBS DPhil</creatorcontrib><creatorcontrib>Subbarao, Padmaja, MD MSc</creatorcontrib><creatorcontrib>Sears, Malcolm R., MBChB</creatorcontrib><creatorcontrib>Takarao, Tim K., MD MSc</creatorcontrib><creatorcontrib>CHILD Study Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Science In Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Psychology</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian Medical Association journal (CMAJ)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tun, Mon H., MBBS MSc</au><au>Kozyrskyj, Anita L., PhD</au><au>Tun, Hein M., DVM PhD</au><au>Mahoney, Justin J., MSc</au><au>Mandhane, Piush J., MD PhD</au><au>Konya, Theodore B., MSc</au><au>Brook, Jeffrey R., PhD</au><au>Lou, Wendy, PhD</au><au>Scott, James A., PhD</au><au>Guttman, David S., PhD</au><au>Becker, Allan B., MD</au><au>Turvey, Stuart E., MBBS DPhil</au><au>Subbarao, Padmaja, MD MSc</au><au>Sears, Malcolm R., MBChB</au><au>Takarao, Tim K., MD MSc</au><aucorp>CHILD Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children</atitle><jtitle>Canadian Medical Association journal (CMAJ)</jtitle><addtitle>CMAJ</addtitle><date>2018-09-17</date><risdate>2018</risdate><volume>190</volume><issue>37</issue><spage>E1097</spage><epage>E1107</epage><pages>E1097-E1107</pages><issn>0820-3946</issn><eissn>1488-2329</eissn><abstract>ABSTRACT BACKGROUND Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score ( p = 0.02) and with increased odds of overweight or obesity ( p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation ( p = 0.2). INTERPRETATION Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.</abstract><cop>Canada</cop><pub>Joule Inc</pub><pmid>30224442</pmid><doi>10.1503/cmaj.170809</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0820-3946 |
| ispartof | Canadian Medical Association journal (CMAJ), 2018-09, Vol.190 (37), p.E1097-E1107 |
| issn | 0820-3946 1488-2329 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6141245 |
| source | DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Age Babies Births Child development Childhood obesity Children & youth Cleaning agents Evaluation Feces Green products Health care Households Internal Medicine Mediation Metabolism Metabolites Microbiota Microbiota (Symbiotic organisms) Obesity Overweight Risk factors Streptococcus infections |
| title | Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T21%3A47%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Postnatal%20exposure%20to%20household%20disinfectants,%20infant%20gut%20microbiota%20and%20subsequent%20risk%20of%20overweight%20in%20children&rft.jtitle=Canadian%20Medical%20Association%20journal%20(CMAJ)&rft.au=Tun,%20Mon%20H.,%20MBBS%20MSc&rft.aucorp=CHILD%20Study%20Investigators&rft.date=2018-09-17&rft.volume=190&rft.issue=37&rft.spage=E1097&rft.epage=E1107&rft.pages=E1097-E1107&rft.issn=0820-3946&rft.eissn=1488-2329&rft_id=info:doi/10.1503/cmaj.170809&rft_dat=%3Cgale_pubme%3EA554494010%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2118268555&rft_id=info:pmid/30224442&rft_galeid=A554494010&rft_els_id=1_s2_0_S0820394618307132&rfr_iscdi=true |