Oral nitrite restores age-dependent phenotypes in eNOS-null mice

Alterations in the synthesis and bioavailability of NO are central to the pathogenesis of cardiovascular and metabolic disorders. Although endothelial NO synthase-derived (eNOS-derived) NO affects mitochondrial long-chain fatty acid β-oxidation, the pathophysiological significance of this regulation...

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Veröffentlicht in:	JCI insight 2018-08, Vol.3 (16)
Hauptverfasser:	Tenopoulou, Margarita, Doulias, Paschalis-Thomas, Nakamoto, Kent, Berrios, Kiara, Zura, Gabriella, Li, Chenxi, Faust, Michael, Yakovishina, Veronika, Evans, Perry, Tan, Lu, Bennett, Michael J, Snyder, Nathaniel W, Quinn, 3rd, William J, Baur, Joseph A, Atochin, Dmitriy N, Huang, Paul L, Ischiropoulos, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aging - drug effects Aging - metabolism Animals Disease Models, Animal Drug Evaluation, Preclinical Fasting - metabolism Homeostasis - drug effects Humans Hyperlipidemias - drug therapy Hyperlipidemias - genetics Hyperlipidemias - metabolism Hypertension - drug therapy Hypertension - genetics Hypertension - metabolism Male Mice Mice, Knockout Nitric Oxide - metabolism Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - genetics Signal Transduction - drug effects Sodium Nitrite - administration & dosage Time Factors Treatment Outcome
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