Administration of recombinant bovine somatotropin prior to fixed-time artificial insemination and the effects on fertility, embryo, and fetal size in beef heifers
Abstract Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hund...
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| Veröffentlicht in: | Journal of animal science 2018-05, Vol.96 (5), p.1894-1902 |
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| creator | Oosthuizen, Nicola Fontes, Pedro L P Henry, Darren D Ciriaco, Francine M Sanford, Carla D Canal, Luara B de Moraes, Gentil V DiLorenzo, Nicolas Currin, John F Clark, Sherrie Whittier, William D Mercadante, Vitor R G Lamb, G Cliff |
| description | Abstract
Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hundred and fourteen Angus-based beef heifers were enrolled in a completely randomized design at 4 locations from January to July of 2016. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) protocol where they received a 100-µg injection of GnRH and a CIDR insert on day −9, 25 mg of PGF2α at CIDR removal on day −2, followed by a 100-µg injection of GnRH and TAI 54 ± 2 h later on day 0. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) heifers that received 650 mg of bST on day −9 (BST; n = 191); or 2) heifers that did not receive bST on day −9 (CONTROL; n = 223). Blood samples were collected on day −9, 0, 28, and 60 to determine the plasma concentrations of IGF-1. Follicle diameter was determined on day −2 and 0 by transrectal ultrasonography. Pregnancy was diagnosed via transrectal ultrasonography on day 28 or 35, and again at least 30 d after the end of the breeding season. Embryo morphometry was assessed by measuring crown-to-rump length (CRL) on day 28, and fetal size was assessed by measuring crown-to-nose-length (CNL) on day 60. Concentrations of plasma IGF-1 did not differ between treatments on day −9 (P = 0.924), 28 (P = 0.075), and 60 (P = 0.792); however, concentrations of plasma IGF-1 were greater (P < 0.001) in BST-treated heifers at TAI (372.4 ± 16.6 vs. 193.7 ± 16.6 ng/ml). No differences (P = 0.191) were detected for follicle diameter between CONTROL and BST treatments on day −2 or 0. Pregnancy rates to TAI (PR/AI) were greater (P = 0.028) for CONTROL compared to BST heifers (42.5 ± 4.0 vs. 29.9 ± 4.1%). No differences (P = 0.536) in CRL were observed on day 28 between CONTROL and BST heifers. In addition, no difference (P = 0.890) was observed for CNL between CONTROL and BST treatments. Final pregnancy rates did not differ (P = 0.699) between treatments. The administration of bST to beef heifers at the initiation of a TAI protocol increased plasma concentrations of IGF-1 at TAI; however, failed to enhance follicle diameter, embryo/fetal size, and reduced PR/AI. |
| doi_str_mv | 10.1093/jas/sky077 |
| format | Article |
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Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hundred and fourteen Angus-based beef heifers were enrolled in a completely randomized design at 4 locations from January to July of 2016. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) protocol where they received a 100-µg injection of GnRH and a CIDR insert on day −9, 25 mg of PGF2α at CIDR removal on day −2, followed by a 100-µg injection of GnRH and TAI 54 ± 2 h later on day 0. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) heifers that received 650 mg of bST on day −9 (BST; n = 191); or 2) heifers that did not receive bST on day −9 (CONTROL; n = 223). Blood samples were collected on day −9, 0, 28, and 60 to determine the plasma concentrations of IGF-1. Follicle diameter was determined on day −2 and 0 by transrectal ultrasonography. Pregnancy was diagnosed via transrectal ultrasonography on day 28 or 35, and again at least 30 d after the end of the breeding season. Embryo morphometry was assessed by measuring crown-to-rump length (CRL) on day 28, and fetal size was assessed by measuring crown-to-nose-length (CNL) on day 60. Concentrations of plasma IGF-1 did not differ between treatments on day −9 (P = 0.924), 28 (P = 0.075), and 60 (P = 0.792); however, concentrations of plasma IGF-1 were greater (P < 0.001) in BST-treated heifers at TAI (372.4 ± 16.6 vs. 193.7 ± 16.6 ng/ml). No differences (P = 0.191) were detected for follicle diameter between CONTROL and BST treatments on day −2 or 0. Pregnancy rates to TAI (PR/AI) were greater (P = 0.028) for CONTROL compared to BST heifers (42.5 ± 4.0 vs. 29.9 ± 4.1%). No differences (P = 0.536) in CRL were observed on day 28 between CONTROL and BST heifers. In addition, no difference (P = 0.890) was observed for CNL between CONTROL and BST treatments. Final pregnancy rates did not differ (P = 0.699) between treatments. The administration of bST to beef heifers at the initiation of a TAI protocol increased plasma concentrations of IGF-1 at TAI; however, failed to enhance follicle diameter, embryo/fetal size, and reduced PR/AI.</description><identifier>ISSN: 0021-8812</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.1093/jas/sky077</identifier><identifier>PMID: 29733416</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Animal reproduction ; Animals ; Artificial insemination ; Beef ; Breeding ; Breeding seasons ; Cattle ; Cattle - embryology ; Cattle - physiology ; Drug delivery systems ; Female ; Fertility ; Fertility - drug effects ; Fetuses ; Gonadotropin-releasing hormone ; Growth Hormone - administration & dosage ; Growth hormones ; Injection ; Insemination, Artificial - veterinary ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - analysis ; Morphometry ; Nose ; Ovarian Follicle - drug effects ; Pregnancy ; Pregnancy Rate ; Random Allocation ; Recombinant Proteins - blood ; Reproduction ; Reproduction (biology) ; Ultrasound</subject><ispartof>Journal of animal science, 2018-05, Vol.96 (5), p.1894-1902</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><rights>Copyright Oxford University Press, UK May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-c07c66a554a8151855ac29258bb25ee6a15aad8829c6f06e755329d6209563a93</citedby><cites>FETCH-LOGICAL-c436t-c07c66a554a8151855ac29258bb25ee6a15aad8829c6f06e755329d6209563a93</cites><orcidid>0000-0001-8130-3617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140887/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140887/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1578,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29733416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oosthuizen, Nicola</creatorcontrib><creatorcontrib>Fontes, Pedro L P</creatorcontrib><creatorcontrib>Henry, Darren D</creatorcontrib><creatorcontrib>Ciriaco, Francine M</creatorcontrib><creatorcontrib>Sanford, Carla D</creatorcontrib><creatorcontrib>Canal, Luara B</creatorcontrib><creatorcontrib>de Moraes, Gentil V</creatorcontrib><creatorcontrib>DiLorenzo, Nicolas</creatorcontrib><creatorcontrib>Currin, John F</creatorcontrib><creatorcontrib>Clark, Sherrie</creatorcontrib><creatorcontrib>Whittier, William D</creatorcontrib><creatorcontrib>Mercadante, Vitor R G</creatorcontrib><creatorcontrib>Lamb, G Cliff</creatorcontrib><title>Administration of recombinant bovine somatotropin prior to fixed-time artificial insemination and the effects on fertility, embryo, and fetal size in beef heifers</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>Abstract
Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hundred and fourteen Angus-based beef heifers were enrolled in a completely randomized design at 4 locations from January to July of 2016. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) protocol where they received a 100-µg injection of GnRH and a CIDR insert on day −9, 25 mg of PGF2α at CIDR removal on day −2, followed by a 100-µg injection of GnRH and TAI 54 ± 2 h later on day 0. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) heifers that received 650 mg of bST on day −9 (BST; n = 191); or 2) heifers that did not receive bST on day −9 (CONTROL; n = 223). Blood samples were collected on day −9, 0, 28, and 60 to determine the plasma concentrations of IGF-1. Follicle diameter was determined on day −2 and 0 by transrectal ultrasonography. Pregnancy was diagnosed via transrectal ultrasonography on day 28 or 35, and again at least 30 d after the end of the breeding season. Embryo morphometry was assessed by measuring crown-to-rump length (CRL) on day 28, and fetal size was assessed by measuring crown-to-nose-length (CNL) on day 60. Concentrations of plasma IGF-1 did not differ between treatments on day −9 (P = 0.924), 28 (P = 0.075), and 60 (P = 0.792); however, concentrations of plasma IGF-1 were greater (P < 0.001) in BST-treated heifers at TAI (372.4 ± 16.6 vs. 193.7 ± 16.6 ng/ml). No differences (P = 0.191) were detected for follicle diameter between CONTROL and BST treatments on day −2 or 0. Pregnancy rates to TAI (PR/AI) were greater (P = 0.028) for CONTROL compared to BST heifers (42.5 ± 4.0 vs. 29.9 ± 4.1%). No differences (P = 0.536) in CRL were observed on day 28 between CONTROL and BST heifers. In addition, no difference (P = 0.890) was observed for CNL between CONTROL and BST treatments. Final pregnancy rates did not differ (P = 0.699) between treatments. The administration of bST to beef heifers at the initiation of a TAI protocol increased plasma concentrations of IGF-1 at TAI; however, failed to enhance follicle diameter, embryo/fetal size, and reduced PR/AI.</description><subject>Animal reproduction</subject><subject>Animals</subject><subject>Artificial insemination</subject><subject>Beef</subject><subject>Breeding</subject><subject>Breeding seasons</subject><subject>Cattle</subject><subject>Cattle - embryology</subject><subject>Cattle - physiology</subject><subject>Drug delivery systems</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility - drug effects</subject><subject>Fetuses</subject><subject>Gonadotropin-releasing hormone</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth hormones</subject><subject>Injection</subject><subject>Insemination, Artificial - veterinary</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Morphometry</subject><subject>Nose</subject><subject>Ovarian Follicle - drug effects</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Random Allocation</subject><subject>Recombinant Proteins - blood</subject><subject>Reproduction</subject><subject>Reproduction (biology)</subject><subject>Ultrasound</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1rFTEUhoMo9ra68QdIQIQiHZuPSSazEUrxCwpudB0ymRNvrjPJNckUrz_HX2rq1KIuXAVOnvPknLwIPaHkJSU9P9-ZfJ6_HEjX3UMbKphoOJX8PtoQwmijFGVH6DjnHSGUiV48REes7zhvqdygHxfj7IPPJZniY8DR4QQ2zoMPJhQ8xGsfAOc4mxJLinsf8D75mHCJ2PlvMDbFz4BNKt55682EfchQlavOhBGXLWBwDmzJuJYcVHby5XCGYR7SIZ79ohyU2pz9d6gGPAA4vAVf4fwIPXBmyvD49jxBn968_nj5rrn68Pb95cVVY1suS2NJZ6U0QrRGUUGVEMayngk1DEwASEOFMaNSrLfSEQmdEJz1o2SkF5Kbnp-gV6t3vwwzjBZC_ZRJ13Vnkw46Gq__vgl-qz_Hay1pS5TqquD0VpDi1wVy0bPPFqbJBIhL1oxw0RHRy5u3nv2D7uKSQl2vUi3tKqZIpV6slE0x5wTubhhK9E30ukav1-gr_PTP8e_Q31lX4PkKxGX_P9FPcUC7NQ</recordid><startdate>20180504</startdate><enddate>20180504</enddate><creator>Oosthuizen, Nicola</creator><creator>Fontes, Pedro L P</creator><creator>Henry, Darren D</creator><creator>Ciriaco, Francine M</creator><creator>Sanford, Carla D</creator><creator>Canal, Luara B</creator><creator>de Moraes, Gentil V</creator><creator>DiLorenzo, Nicolas</creator><creator>Currin, John F</creator><creator>Clark, Sherrie</creator><creator>Whittier, William D</creator><creator>Mercadante, Vitor R G</creator><creator>Lamb, G Cliff</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8130-3617</orcidid></search><sort><creationdate>20180504</creationdate><title>Administration of recombinant bovine somatotropin prior to fixed-time artificial insemination and the effects on fertility, embryo, and fetal size in beef heifers</title><author>Oosthuizen, Nicola ; Fontes, Pedro L P ; Henry, Darren D ; Ciriaco, Francine M ; Sanford, Carla D ; Canal, Luara B ; de Moraes, Gentil V ; DiLorenzo, Nicolas ; Currin, John F ; Clark, Sherrie ; Whittier, William D ; Mercadante, Vitor R G ; Lamb, G Cliff</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-c07c66a554a8151855ac29258bb25ee6a15aad8829c6f06e755329d6209563a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal reproduction</topic><topic>Animals</topic><topic>Artificial insemination</topic><topic>Beef</topic><topic>Breeding</topic><topic>Breeding seasons</topic><topic>Cattle</topic><topic>Cattle - embryology</topic><topic>Cattle - physiology</topic><topic>Drug delivery systems</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility - drug effects</topic><topic>Fetuses</topic><topic>Gonadotropin-releasing hormone</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth hormones</topic><topic>Injection</topic><topic>Insemination, Artificial - veterinary</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Morphometry</topic><topic>Nose</topic><topic>Ovarian Follicle - drug effects</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Random Allocation</topic><topic>Recombinant Proteins - blood</topic><topic>Reproduction</topic><topic>Reproduction (biology)</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oosthuizen, Nicola</creatorcontrib><creatorcontrib>Fontes, Pedro L P</creatorcontrib><creatorcontrib>Henry, Darren D</creatorcontrib><creatorcontrib>Ciriaco, Francine M</creatorcontrib><creatorcontrib>Sanford, Carla D</creatorcontrib><creatorcontrib>Canal, Luara B</creatorcontrib><creatorcontrib>de Moraes, Gentil V</creatorcontrib><creatorcontrib>DiLorenzo, Nicolas</creatorcontrib><creatorcontrib>Currin, John F</creatorcontrib><creatorcontrib>Clark, Sherrie</creatorcontrib><creatorcontrib>Whittier, William D</creatorcontrib><creatorcontrib>Mercadante, Vitor R G</creatorcontrib><creatorcontrib>Lamb, G Cliff</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oosthuizen, Nicola</au><au>Fontes, Pedro L P</au><au>Henry, Darren D</au><au>Ciriaco, Francine M</au><au>Sanford, Carla D</au><au>Canal, Luara B</au><au>de Moraes, Gentil V</au><au>DiLorenzo, Nicolas</au><au>Currin, John F</au><au>Clark, Sherrie</au><au>Whittier, William D</au><au>Mercadante, Vitor R G</au><au>Lamb, G Cliff</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Administration of recombinant bovine somatotropin prior to fixed-time artificial insemination and the effects on fertility, embryo, and fetal size in beef heifers</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>2018-05-04</date><risdate>2018</risdate><volume>96</volume><issue>5</issue><spage>1894</spage><epage>1902</epage><pages>1894-1902</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><abstract>Abstract
Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hundred and fourteen Angus-based beef heifers were enrolled in a completely randomized design at 4 locations from January to July of 2016. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) protocol where they received a 100-µg injection of GnRH and a CIDR insert on day −9, 25 mg of PGF2α at CIDR removal on day −2, followed by a 100-µg injection of GnRH and TAI 54 ± 2 h later on day 0. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) heifers that received 650 mg of bST on day −9 (BST; n = 191); or 2) heifers that did not receive bST on day −9 (CONTROL; n = 223). Blood samples were collected on day −9, 0, 28, and 60 to determine the plasma concentrations of IGF-1. Follicle diameter was determined on day −2 and 0 by transrectal ultrasonography. Pregnancy was diagnosed via transrectal ultrasonography on day 28 or 35, and again at least 30 d after the end of the breeding season. Embryo morphometry was assessed by measuring crown-to-rump length (CRL) on day 28, and fetal size was assessed by measuring crown-to-nose-length (CNL) on day 60. Concentrations of plasma IGF-1 did not differ between treatments on day −9 (P = 0.924), 28 (P = 0.075), and 60 (P = 0.792); however, concentrations of plasma IGF-1 were greater (P < 0.001) in BST-treated heifers at TAI (372.4 ± 16.6 vs. 193.7 ± 16.6 ng/ml). No differences (P = 0.191) were detected for follicle diameter between CONTROL and BST treatments on day −2 or 0. Pregnancy rates to TAI (PR/AI) were greater (P = 0.028) for CONTROL compared to BST heifers (42.5 ± 4.0 vs. 29.9 ± 4.1%). No differences (P = 0.536) in CRL were observed on day 28 between CONTROL and BST heifers. In addition, no difference (P = 0.890) was observed for CNL between CONTROL and BST treatments. Final pregnancy rates did not differ (P = 0.699) between treatments. The administration of bST to beef heifers at the initiation of a TAI protocol increased plasma concentrations of IGF-1 at TAI; however, failed to enhance follicle diameter, embryo/fetal size, and reduced PR/AI.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29733416</pmid><doi>10.1093/jas/sky077</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8130-3617</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8812 |
| ispartof | Journal of animal science, 2018-05, Vol.96 (5), p.1894-1902 |
| issn | 0021-8812 1525-3163 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6140887 |
| source | MEDLINE; Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal reproduction Animals Artificial insemination Beef Breeding Breeding seasons Cattle Cattle - embryology Cattle - physiology Drug delivery systems Female Fertility Fertility - drug effects Fetuses Gonadotropin-releasing hormone Growth Hormone - administration & dosage Growth hormones Injection Insemination, Artificial - veterinary Insulin-like growth factor I Insulin-Like Growth Factor I - analysis Morphometry Nose Ovarian Follicle - drug effects Pregnancy Pregnancy Rate Random Allocation Recombinant Proteins - blood Reproduction Reproduction (biology) Ultrasound |
| title | Administration of recombinant bovine somatotropin prior to fixed-time artificial insemination and the effects on fertility, embryo, and fetal size in beef heifers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T13%3A44%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Administration%20of%20recombinant%20bovine%20somatotropin%20prior%20to%20fixed-time%20artificial%20insemination%20and%20the%20effects%20on%20fertility,%20embryo,%20and%20fetal%20size%20in%20beef%20heifers&rft.jtitle=Journal%20of%20animal%20science&rft.au=Oosthuizen,%20Nicola&rft.date=2018-05-04&rft.volume=96&rft.issue=5&rft.spage=1894&rft.epage=1902&rft.pages=1894-1902&rft.issn=0021-8812&rft.eissn=1525-3163&rft_id=info:doi/10.1093/jas/sky077&rft_dat=%3Cproquest_pubme%3E2041770580%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2041770580&rft_id=info:pmid/29733416&rft_oup_id=10.1093/jas/sky077&rfr_iscdi=true |