Queuosine modification protects cognate tRNAs against ribonuclease cleavage

Eukaryotic transfer RNAs (tRNA) contain on average 13 modifications that perform a wide range of roles in translation and in the generation of tRNA fragments that regulate gene expression. Queuosine (Q) modification occurs in the wobble anticodon position of tRNAs for amino acids His, Asn, Tyr, and...

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Veröffentlicht in:	RNA (Cambridge) 2018-10, Vol.24 (10), p.1305-1313
Hauptverfasser:	Wang, Xiaoyun, Matuszek, Zaneta, Huang, Yong, Parisien, Marc, Dai, Qing, Clark, Wesley, Schwartz, Michael H, Pan, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenin Anticodon Cell Line Cell lines Eukaryotes Gene expression Humans Intestinal microflora Microbiomes Nucleoside Q - genetics Nucleoside Q - metabolism Queuosine Ribonuclease Ribonuclease, Pancreatic - metabolism Ribonuclease, Pancreatic - pharmacology Ribonucleases - metabolism Ribonucleic acid RNA RNA Cleavage RNA modification RNA Processing, Post-Transcriptional RNA, Transfer - genetics RNA, Transfer - metabolism Stress, Physiological - drug effects Stress, Physiological - genetics tRNA
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