Tumor necrosis factor alpha reduces intestinal vitamin C uptake: a role for NF-κB-mediated signaling

Sodium-dependent vitamin C transporter-1 (SVCT-1) is the major transporter mediating intestinal vitamin C uptake. Intestinal inflammation and prolonged infection are associated with increased serum and intestinal mucosa levels of tumor necrosis factor-α (TNF-α), which also exerts profound effects on...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2018-08, Vol.315 (2), p.G241-G248
Hauptverfasser:	Subramanian, Veedamali S, Sabui, Subrata, Subramenium, Ganapathy A, Marchant, Jonathan S, Said, Hamid M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic acid Digestive system Gene expression Inflammation Inflammatory bowel diseases Intestinal absorption Intestine Jejunum Malabsorption Mucosa NF-κB protein Nutrients Pathogenesis Patients Sodium Transcription Tumor necrosis factor-TNF Tumor necrosis factor-α Vitamin C
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