The gastric mucosal-associated microbiome in patients with gastric polyposis
The characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric p...
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| description | The characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric polyps (GP.A, GP.B and GP.P group) for 16S rDNA sequencing. The results showed that the diversity of the gastric flora in the GP group was significantly lower than that of the HC group. The gastric flora composition of the GP group was significantly different from the HC group. However, flora diversity and compositions in different parts of the stomach (gastric antrum, gastric body or polyp tissue) were not significantly different.
H. pylori
abundance could influence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions. We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These findings showed that intragastric flora dysbiosis may be closely related to the occurrence and development of gastric polyps. |
| doi_str_mv | 10.1038/s41598-018-31738-2 |
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H. pylori
abundance could influence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions. We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These findings showed that intragastric flora dysbiosis may be closely related to the occurrence and development of gastric polyps.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-31738-2</identifier><identifier>PMID: 30217998</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/23 ; 631/326/107 ; 692/4020/1503/1828 ; Adenomatous Polyposis Coli - pathology ; Adenomatous Polyps - microbiology ; Adenomatous Polyps - pathology ; Adult ; Aged ; Biopsy ; China ; Dysbacteriosis ; Female ; Flora ; Gastric Fundus - pathology ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; Gastrointestinal Microbiome ; Helicobacter pylori ; Humanities and Social Sciences ; Humans ; Male ; Microbiomes ; Microbiota ; Middle Aged ; Mucosa ; multidisciplinary ; Polyposis ; Polyps ; Polyps - pathology ; Prediction models ; Pyloric Antrum - pathology ; rRNA 16S ; Science ; Science (multidisciplinary) ; Stomach ; Stomach - pathology ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology</subject><ispartof>Scientific reports, 2018-09, Vol.8 (1), p.13817-9, Article 13817</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b670bb8b56deeba6c2eb6d4126311a927728175db0d0512fa2fe0a86ec7342953</citedby><cites>FETCH-LOGICAL-c474t-b670bb8b56deeba6c2eb6d4126311a927728175db0d0512fa2fe0a86ec7342953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138709/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138709/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30217998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Rongrong</creatorcontrib><creatorcontrib>Wang, Zikai</creatorcontrib><creatorcontrib>Sun, Huaibo</creatorcontrib><creatorcontrib>Gao, Xuefeng</creatorcontrib><creatorcontrib>Sun, Gang</creatorcontrib><creatorcontrib>Peng, Lihua</creatorcontrib><creatorcontrib>Yan, Bin</creatorcontrib><creatorcontrib>Yang, Yunsheng</creatorcontrib><title>The gastric mucosal-associated microbiome in patients with gastric polyposis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric polyps (GP.A, GP.B and GP.P group) for 16S rDNA sequencing. The results showed that the diversity of the gastric flora in the GP group was significantly lower than that of the HC group. The gastric flora composition of the GP group was significantly different from the HC group. However, flora diversity and compositions in different parts of the stomach (gastric antrum, gastric body or polyp tissue) were not significantly different.
H. pylori
abundance could influence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions. We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These findings showed that intragastric flora dysbiosis may be closely related to the occurrence and development of gastric polyps.</description><subject>45</subject><subject>45/23</subject><subject>631/326/107</subject><subject>692/4020/1503/1828</subject><subject>Adenomatous Polyposis Coli - pathology</subject><subject>Adenomatous Polyps - microbiology</subject><subject>Adenomatous Polyps - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biopsy</subject><subject>China</subject><subject>Dysbacteriosis</subject><subject>Female</subject><subject>Flora</subject><subject>Gastric Fundus - pathology</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastrointestinal Microbiome</subject><subject>Helicobacter pylori</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>multidisciplinary</subject><subject>Polyposis</subject><subject>Polyps</subject><subject>Polyps - pathology</subject><subject>Prediction models</subject><subject>Pyloric Antrum - pathology</subject><subject>rRNA 16S</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Stomach</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9P3DAQxS1UBAj4AhxQJC69BOyxEzsXpAqVP9JKXOBs2Y531yiJU0_Sim9fw8IWesAXW5rfe56ZR8gJo-eMcnWBglWNKilTJWeSqxJ2yAFQUZXAAb59eO-TY8Qnmk8FjWDNHtnnFJhsGnVAFg9rX6wMTim4op9dRNOVBjG6YCbfFn1wKdoQe1-EoRjNFPwwYfEnTOutbIzd8xgx4BHZXZoO_fHbfUger38-XN2Wi_ubu6sfi9IJKabS1pJaq2xVt95bUzvwtm4Fg5ozZhqQEhSTVWtpSysGSwNLT42qvZNcQFPxQ3K58R1n2_vW5ZaS6fSYQm_Ss44m6M-VIaz1Kv7WNeNK0iYbfH8zSPHX7HHSfUDnu84MPs6ogdEqr48KmdGz_9CnOKchj_dC5RAEAM8UbKi8LcTkl9tmGNUveelNXjrnpV_z0pBFpx_H2Ere08kA3wCYS8PKp39_f2H7F-unoWg</recordid><startdate>20180914</startdate><enddate>20180914</enddate><creator>Ren, Rongrong</creator><creator>Wang, Zikai</creator><creator>Sun, Huaibo</creator><creator>Gao, Xuefeng</creator><creator>Sun, Gang</creator><creator>Peng, Lihua</creator><creator>Yan, Bin</creator><creator>Yang, Yunsheng</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180914</creationdate><title>The gastric mucosal-associated microbiome in patients with gastric polyposis</title><author>Ren, Rongrong ; Wang, Zikai ; Sun, Huaibo ; Gao, Xuefeng ; Sun, Gang ; Peng, Lihua ; Yan, Bin ; Yang, Yunsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b670bb8b56deeba6c2eb6d4126311a927728175db0d0512fa2fe0a86ec7342953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>45</topic><topic>45/23</topic><topic>631/326/107</topic><topic>692/4020/1503/1828</topic><topic>Adenomatous Polyposis Coli - pathology</topic><topic>Adenomatous Polyps - microbiology</topic><topic>Adenomatous Polyps - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biopsy</topic><topic>China</topic><topic>Dysbacteriosis</topic><topic>Female</topic><topic>Flora</topic><topic>Gastric Fundus - pathology</topic><topic>Gastric Mucosa - microbiology</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastrointestinal Microbiome</topic><topic>Helicobacter pylori</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>multidisciplinary</topic><topic>Polyposis</topic><topic>Polyps</topic><topic>Polyps - pathology</topic><topic>Prediction models</topic><topic>Pyloric Antrum - pathology</topic><topic>rRNA 16S</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Stomach</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Rongrong</creatorcontrib><creatorcontrib>Wang, Zikai</creatorcontrib><creatorcontrib>Sun, Huaibo</creatorcontrib><creatorcontrib>Gao, Xuefeng</creatorcontrib><creatorcontrib>Sun, Gang</creatorcontrib><creatorcontrib>Peng, Lihua</creatorcontrib><creatorcontrib>Yan, Bin</creatorcontrib><creatorcontrib>Yang, Yunsheng</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Rongrong</au><au>Wang, Zikai</au><au>Sun, Huaibo</au><au>Gao, Xuefeng</au><au>Sun, Gang</au><au>Peng, Lihua</au><au>Yan, Bin</au><au>Yang, Yunsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The gastric mucosal-associated microbiome in patients with gastric polyposis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-09-14</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>13817</spage><epage>9</epage><pages>13817-9</pages><artnum>13817</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric polyps (GP.A, GP.B and GP.P group) for 16S rDNA sequencing. The results showed that the diversity of the gastric flora in the GP group was significantly lower than that of the HC group. The gastric flora composition of the GP group was significantly different from the HC group. However, flora diversity and compositions in different parts of the stomach (gastric antrum, gastric body or polyp tissue) were not significantly different.
H. pylori
abundance could influence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions. We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These findings showed that intragastric flora dysbiosis may be closely related to the occurrence and development of gastric polyps.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30217998</pmid><doi>10.1038/s41598-018-31738-2</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45 45/23 631/326/107 692/4020/1503/1828 Adenomatous Polyposis Coli - pathology Adenomatous Polyps - microbiology Adenomatous Polyps - pathology Adult Aged Biopsy China Dysbacteriosis Female Flora Gastric Fundus - pathology Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastrointestinal Microbiome Helicobacter pylori Humanities and Social Sciences Humans Male Microbiomes Microbiota Middle Aged Mucosa multidisciplinary Polyposis Polyps Polyps - pathology Prediction models Pyloric Antrum - pathology rRNA 16S Science Science (multidisciplinary) Stomach Stomach - pathology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology |
| title | The gastric mucosal-associated microbiome in patients with gastric polyposis |
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