Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons

A ten-eleven translocation (TET) ortholog exists as a DNA N6-methyladenine (6mA) demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD remain unexplored. Through genome-wide 6mA and transcriptome profiling in Drosophila brains and neuronal cells, we found that 6mA may epigen...

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Veröffentlicht in:	Molecular cell 2018-09, Vol.71 (5), p.848-857.e6
Hauptverfasser:	Yao, Bing, Li, Yujing, Wang, Zhiqin, Chen, Li, Poidevin, Mickael, Zhang, Can, Lin, Li, Wang, Feng, Bao, Han, Jiao, Bin, Lim, Junghwa, Cheng, Ying, Huang, Luoxiu, Phillips, Brittany Lynn, Xu, Tianlei, Duan, Ranhui, Moberg, Kenneth H., Wu, Hao, Jin, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	6-methyladenine brain demethylation DNA Drosophila enzymes epigenetics gene expression genes neurodevelopment neuron neurons Polycomb proteins transcription (genetics) transcriptomics
Online-Zugang:	Volltext
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