Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea
Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus. Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the in...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-8 |
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| creator | Bnouham, Mohamed Aziz, Mohammed Ziyyat, A. Mekhfi, H. Bouhrim, Mohamed Bouknana, Saliha Zahidi, Touda Ouassou, Hayat Legssyer, A. |
| description | Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus. Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Caralluma europaea (CE) on α-glucosidase activity in vitro; then the kinetics of the enzyme were studied with increasing concentrations of sucrose in order to determine the inhibition type of the enzyme. In addition, this effect of Caralluma europaea (CE) was confirmed in vivo using rats as an experimental animal model. Among the five fractions of CE, only the ethyl acetate fraction of C. europaea (EACe) induced a significant inhibition of α-glucosidase and its inhibition mode was competitive. The in vivo studies were conducted on mice and rats using glucose and sucrose as a substrate, respectively, to determine the oral glucose tolerance test (OGTT). The results obtained showed that the EACe and the aqueous extract of C. europaea (AECe) have significantly reduced the postprandial hyperglycemia after sucrose and glucose loading in normal and diabetic rats. AECe, also, significantly decreased intestinal glucose absorption, in situ. The results obtained showed that Caralluma europaea has a significant antihyperglycemic activity, which could be due to the inhibition of α-glucosidase activity and enteric absorption of glucose. |
| doi_str_mv | 10.1155/2018/9589472 |
| format | Article |
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Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Caralluma europaea (CE) on α-glucosidase activity in vitro; then the kinetics of the enzyme were studied with increasing concentrations of sucrose in order to determine the inhibition type of the enzyme. In addition, this effect of Caralluma europaea (CE) was confirmed in vivo using rats as an experimental animal model. Among the five fractions of CE, only the ethyl acetate fraction of C. europaea (EACe) induced a significant inhibition of α-glucosidase and its inhibition mode was competitive. The in vivo studies were conducted on mice and rats using glucose and sucrose as a substrate, respectively, to determine the oral glucose tolerance test (OGTT). The results obtained showed that the EACe and the aqueous extract of C. europaea (AECe) have significantly reduced the postprandial hyperglycemia after sucrose and glucose loading in normal and diabetic rats. AECe, also, significantly decreased intestinal glucose absorption, in situ. The results obtained showed that Caralluma europaea has a significant antihyperglycemic activity, which could be due to the inhibition of α-glucosidase activity and enteric absorption of glucose.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/9589472</identifier><identifier>PMID: 30228829</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Absorption ; Acetic acid ; Antidiabetics ; Chemical compounds ; Chloride ; Chronic illnesses ; Diabetes ; Diabetes mellitus ; Ethyl acetate ; Glucose ; Glucose tolerance ; Glucosidase ; Herbal medicine ; Hyperglycemia ; Inhibition ; Insulin resistance ; Intestine ; Kinetics ; Medicinal plants ; Metabolism ; Pharmaceuticals ; Pharmacy ; Rats ; Side effects ; Sucrose ; Sugar ; Therapeutic applications ; α-Glucosidase</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-8</ispartof><rights>Copyright © 2018 Hayat Ouassou et al.</rights><rights>Copyright © 2018 Hayat Ouassou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Hayat Ouassou et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-ae7b85b1a695a05cda43228d3527a5d63f04d5006f26f7688d39764d26714d6d3</citedby><cites>FETCH-LOGICAL-c471t-ae7b85b1a695a05cda43228d3527a5d63f04d5006f26f7688d39764d26714d6d3</cites><orcidid>0000-0001-6384-2537 ; 0000-0002-3006-2523 ; 0000-0003-1295-9588 ; 0000-0001-9473-1290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136516/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136516/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30228829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Harris, Cory S.</contributor><contributor>Cory S Harris</contributor><creatorcontrib>Bnouham, Mohamed</creatorcontrib><creatorcontrib>Aziz, Mohammed</creatorcontrib><creatorcontrib>Ziyyat, A.</creatorcontrib><creatorcontrib>Mekhfi, H.</creatorcontrib><creatorcontrib>Bouhrim, Mohamed</creatorcontrib><creatorcontrib>Bouknana, Saliha</creatorcontrib><creatorcontrib>Zahidi, Touda</creatorcontrib><creatorcontrib>Ouassou, Hayat</creatorcontrib><creatorcontrib>Legssyer, A.</creatorcontrib><title>Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus. Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Caralluma europaea (CE) on α-glucosidase activity in vitro; then the kinetics of the enzyme were studied with increasing concentrations of sucrose in order to determine the inhibition type of the enzyme. In addition, this effect of Caralluma europaea (CE) was confirmed in vivo using rats as an experimental animal model. Among the five fractions of CE, only the ethyl acetate fraction of C. europaea (EACe) induced a significant inhibition of α-glucosidase and its inhibition mode was competitive. The in vivo studies were conducted on mice and rats using glucose and sucrose as a substrate, respectively, to determine the oral glucose tolerance test (OGTT). The results obtained showed that the EACe and the aqueous extract of C. europaea (AECe) have significantly reduced the postprandial hyperglycemia after sucrose and glucose loading in normal and diabetic rats. AECe, also, significantly decreased intestinal glucose absorption, in situ. The results obtained showed that Caralluma europaea has a significant antihyperglycemic activity, which could be due to the inhibition of α-glucosidase activity and enteric absorption of glucose.</description><subject>Absorption</subject><subject>Acetic acid</subject><subject>Antidiabetics</subject><subject>Chemical compounds</subject><subject>Chloride</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Ethyl acetate</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glucosidase</subject><subject>Herbal medicine</subject><subject>Hyperglycemia</subject><subject>Inhibition</subject><subject>Insulin resistance</subject><subject>Intestine</subject><subject>Kinetics</subject><subject>Medicinal plants</subject><subject>Metabolism</subject><subject>Pharmaceuticals</subject><subject>Pharmacy</subject><subject>Rats</subject><subject>Side 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Glucose Absorption, and Antidiabetic Properties by Caralluma europaea</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus. Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Caralluma europaea (CE) on α-glucosidase activity in vitro; then the kinetics of the enzyme were studied with increasing concentrations of sucrose in order to determine the inhibition type of the enzyme. In addition, this effect of Caralluma europaea (CE) was confirmed in vivo using rats as an experimental animal model. Among the five fractions of CE, only the ethyl acetate fraction of C. europaea (EACe) induced a significant inhibition of α-glucosidase and its inhibition mode was competitive. The in vivo studies were conducted on mice and rats using glucose and sucrose as a substrate, respectively, to determine the oral glucose tolerance test (OGTT). The results obtained showed that the EACe and the aqueous extract of C. europaea (AECe) have significantly reduced the postprandial hyperglycemia after sucrose and glucose loading in normal and diabetic rats. AECe, also, significantly decreased intestinal glucose absorption, in situ. The results obtained showed that Caralluma europaea has a significant antihyperglycemic activity, which could be due to the inhibition of α-glucosidase activity and enteric absorption of glucose.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30228829</pmid><doi>10.1155/2018/9589472</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6384-2537</orcidid><orcidid>https://orcid.org/0000-0002-3006-2523</orcidid><orcidid>https://orcid.org/0000-0003-1295-9588</orcidid><orcidid>https://orcid.org/0000-0001-9473-1290</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Absorption Acetic acid Antidiabetics Chemical compounds Chloride Chronic illnesses Diabetes Diabetes mellitus Ethyl acetate Glucose Glucose tolerance Glucosidase Herbal medicine Hyperglycemia Inhibition Insulin resistance Intestine Kinetics Medicinal plants Metabolism Pharmaceuticals Pharmacy Rats Side effects Sucrose Sugar Therapeutic applications α-Glucosidase |
| title | Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea |
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