Mast Cells in the Developing Brain Determine Adult Sexual Behavior

Many sex differences in brain and behavior are programmed during development by gonadal hormones, but the cellular mechanisms are incompletely understood. We found that immune-system-derived mast cells are a primary target for the masculinizing hormone estradiol and that mast cells are in turn prima...

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Veröffentlicht in:	The Journal of neuroscience 2018-09, Vol.38 (37), p.8044-8059
Hauptverfasser:	Lenz, Kathryn M, Pickett, Lindsay A, Wright, Christopher L, Davis, Katherine T, Joshi, Aarohi, McCarthy, Margaret M
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Brain Cell number Copulation Critical period Differentiation Females Gender aspects Gender differences Histamine Hormones Mast cells Microglia Morphology Preoptic area Prostaglandins Sex differentiation Sex hormones Sexual behavior
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