Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Using a Quantitative High-throughput Screening Platform

Abstract The androgen receptor (AR, NR3C4) is a nuclear receptor whose main function is acting as a transcription factor regulating gene expression for male sexual development and maintaining accessory sexual organ function. It is also a necessary component of female fertility by affecting the funct...

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Veröffentlicht in:	Toxicology (Amsterdam) 2017-06, Vol.385, p.48-58
Hauptverfasser:	Lynch, Caitlin, Sakamuru, Srilatha, Huang, Ruili, Stavreva, Diana A, Varticovski, Lyuba, Hager, Gordon L, Judson, Richard S, Houck, Keith A, Kleinstreuer, Nicole C, Casey, Warren, Paules, Richard S, Simeonov, Anton, Xia, Menghang
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Androgen receptor androgen receptors Androgens - pharmacology beta-lactamase beta-Lactamases - genetics Cell Line cytoplasm Emergency endocrine-disrupting chemicals female fertility gene expression Genes, Reporter High-Throughput Screening Assays Humans Luciferases - genetics males Modulators neoplasms ovarian follicles ovulation Receptors, Androgen - genetics Receptors, Androgen - metabolism reporter genes screening sexual development testes testosterone Tox21 10K compound library Translocation
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