Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Plasmodium falciparum multidrug resistance constitutes a major obstacle to the global malaria elimination campaign. Specific mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediate resistance to the 4-aminoquinoline drug chloroquine and impact parasite susceptibilit...

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Veröffentlicht in:	Scientific reports 2018-09, Vol.8 (1), p.13578-13, Article 13578
Hauptverfasser:	Lee, Andrew H., Dhingra, Satish K., Lewis, Ian A., Singh, Maneesh K., Siriwardana, Amila, Dalal, Seema, Rubiano, Kelly, Klein, Matthias S., Baska, Katelynn S., Krishna, Sanjeev, Klemba, Michael, Roepe, Paul D., Llinás, Manuel, Garcia, Celia R. S., Fidock, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 14/63 38/22 38/23 38/77 42/41 45 631/208 631/326/88 Amino acids Amodiaquine Amodiaquine - pharmacology Antimalarials - pharmacology Artemisinin Artemisinins - pharmacology Calcium Calcium - metabolism Cells, Cultured Chloroquine Chloroquine - pharmacology Drug Resistance, Multiple - genetics Erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - parasitology Gene Expression Heme Hemoglobin Hemoglobins - metabolism Host-Parasite Interactions Humanities and Social Sciences Humans Ion Transport - drug effects Ionophores Ionophores - pharmacology Isoforms Malaria Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Metabolomics Methionine Monensin Monensin - pharmacology multidisciplinary Multidrug resistance Mutation Nigericin Nigericin - pharmacology Parasites Peptides Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Protozoan Proteins - genetics Protozoan Proteins - metabolism Pyrrolidinones - pharmacology Reproductive fitness Science Science (multidisciplinary) Vector-borne diseases
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