Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents
Rodent models of sciatic nerve lesion are regularly used to assess functional deficits in nerves. Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, littl...
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| Veröffentlicht in: | Scientific reports 2018-09, Vol.8 (1), p.13585-9, Article 13585 |
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| creator | Tajino, Junichi Ito, Akira Tanima, Momoko Yamaguchi, Shoki Iijima, Hirotaka Nakahata, Akihiro Kiyan, Wataru Aoyama, Tomoki Kuroki, Hiroshi |
| description | Rodent models of sciatic nerve lesion are regularly used to assess functional deficits in nerves. Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. A broad application of these methods will improve understanding and standardized motor assessment. |
| doi_str_mv | 10.1038/s41598-018-31579-z |
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Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. A broad application of these methods will improve understanding and standardized motor assessment.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-31579-z</identifier><identifier>PMID: 30206259</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 631/378/2632/1664 ; 692/308/575 ; Animal models ; Dimensional analysis ; Gait ; Humanities and Social Sciences ; Lesions ; multidisciplinary ; Nerves ; Rodents ; Sciatic nerve ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2018-09, Vol.8 (1), p.13585-9, Article 13585</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. 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Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. 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| subjects | 59 631/378/2632/1664 692/308/575 Animal models Dimensional analysis Gait Humanities and Social Sciences Lesions multidisciplinary Nerves Rodents Sciatic nerve Science Science (multidisciplinary) |
| title | Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents |
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