Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with...
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| Veröffentlicht in: | Molecular neurobiology 2018-10, Vol.55 (10), p.7886-7899 |
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| description | Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with AD. To investigate the anatomical connections of the hippocampus, we injected the neurotracer 1,1′-dioctadecyl-3,3,3′3,3′-tetramethyl-indocarbocyanine perchlorate (DiI) into the hippocampi of 5XFAD mice, which were used as an animal model of AD. In wild-type controls, DiI-containing cells were found in the entorhinal cortex, medial septum, locus coeruleus, dorsal raphe, substantia nigra pars compacta, and olfactory bulb. Hippocampal inputs were decreased in multiple brain regions in the 5XFAD mice compared to wild-type littermate mice. These results are the first to reveal alterations at the cellular level in hippocampal connectivity in the brains of 5XFAD mice. These results suggest that anatomical mapping of hippocampal connectivity will elucidate new pathogenic mechanisms and therapeutic targets for AD treatment. |
| doi_str_mv | 10.1007/s12035-018-0918-y |
| format | Article |
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Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with AD. To investigate the anatomical connections of the hippocampus, we injected the neurotracer 1,1′-dioctadecyl-3,3,3′3,3′-tetramethyl-indocarbocyanine perchlorate (DiI) into the hippocampi of 5XFAD mice, which were used as an animal model of AD. In wild-type controls, DiI-containing cells were found in the entorhinal cortex, medial septum, locus coeruleus, dorsal raphe, substantia nigra pars compacta, and olfactory bulb. Hippocampal inputs were decreased in multiple brain regions in the 5XFAD mice compared to wild-type littermate mice. These results are the first to reveal alterations at the cellular level in hippocampal connectivity in the brains of 5XFAD mice. These results suggest that anatomical mapping of hippocampal connectivity will elucidate new pathogenic mechanisms and therapeutic targets for AD treatment.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-018-0918-y</identifier><identifier>PMID: 29488134</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer Disease - pathology ; Alzheimer's disease ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Cognitive ability ; Cortex (entorhinal) ; Disease Models, Animal ; Entorhinal Cortex - pathology ; Hippocampus ; Hippocampus - pathology ; Humans ; Locus coeruleus ; Locus Coeruleus - pathology ; Mice ; Mice, Transgenic ; Nerve Net - pathology ; Neural networks ; Neurobiology ; Neurodegeneration ; Neurodegenerative diseases ; Neurology ; Neurons - pathology ; Neurosciences ; Olfactory bulb ; Olfactory Bulb - pathology ; Olfactory stimuli ; Perchlorate ; Perchloric acid ; Raphe Nuclei - pathology ; Reproducibility of Results ; Rodents ; Septum ; Substantia nigra ; Substantia Nigra - pathology ; Visualization</subject><ispartof>Molecular neurobiology, 2018-10, Vol.55 (10), p.7886-7899</ispartof><rights>The Author(s) 2018</rights><rights>Molecular Neurobiology is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-18597523e894f019dcc73ae4d53f36b291c39389beb143c0d0c8c2d7e9708fcb3</citedby><cites>FETCH-LOGICAL-c536t-18597523e894f019dcc73ae4d53f36b291c39389beb143c0d0c8c2d7e9708fcb3</cites><orcidid>0000-0002-8140-5928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-018-0918-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-018-0918-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29488134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Seong Gak</creatorcontrib><creatorcontrib>Kim, Yong Jun</creatorcontrib><creatorcontrib>Kim, Kyoung Ah</creatorcontrib><creatorcontrib>Mook-Jung, Inhee</creatorcontrib><creatorcontrib>Moon, Minho</creatorcontrib><title>Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with AD. To investigate the anatomical connections of the hippocampus, we injected the neurotracer 1,1′-dioctadecyl-3,3,3′3,3′-tetramethyl-indocarbocyanine perchlorate (DiI) into the hippocampi of 5XFAD mice, which were used as an animal model of AD. In wild-type controls, DiI-containing cells were found in the entorhinal cortex, medial septum, locus coeruleus, dorsal raphe, substantia nigra pars compacta, and olfactory bulb. Hippocampal inputs were decreased in multiple brain regions in the 5XFAD mice compared to wild-type littermate mice. These results are the first to reveal alterations at the cellular level in hippocampal connectivity in the brains of 5XFAD mice. These results suggest that anatomical mapping of hippocampal connectivity will elucidate new pathogenic mechanisms and therapeutic targets for AD treatment.</description><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cognitive ability</subject><subject>Cortex (entorhinal)</subject><subject>Disease Models, Animal</subject><subject>Entorhinal Cortex - pathology</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Locus coeruleus</subject><subject>Locus Coeruleus - pathology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Nerve Net - pathology</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Neurosciences</subject><subject>Olfactory bulb</subject><subject>Olfactory Bulb - pathology</subject><subject>Olfactory stimuli</subject><subject>Perchlorate</subject><subject>Perchloric acid</subject><subject>Raphe Nuclei - pathology</subject><subject>Reproducibility of Results</subject><subject>Rodents</subject><subject>Septum</subject><subject>Substantia nigra</subject><subject>Substantia Nigra - pathology</subject><subject>Visualization</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1DAUhS1ERYeBB2CDIrFhE7i2k7G9QRoNhSK1YgPskOU4N62rxA52Umm66mvwejwJHqWUH4mNvTjfOb7Xh5BnFF5RAPE6UQa8LoHKElQ-9g_Iita1KimV7CFZgVS8FJtKHpPHKV0BMEZBPCLHTFVSUl6tyNcvLs2mdzdmcsEXoSu2_YQR2-LUjWOwZhhNX-yC92gnd-2mfeF8YXyx9W7IynlosV9sN5foBow_br-n4q1LaBI-IUed6RM-vbvX5PO7k0-70_Ls4_sPu-1ZaWu-mUoqayVqxlGqqgOqWmsFN1i1Ne_4pmGKWq64VA02tOIWWrDSslagEiA72_A1ebPkjnMzYGvRT9H0eox5xrjXwTj9t-Ldpb4I13pDORM5e01e3gXE8G3GNOnBJYt9bzyGOWkGoFj-MEUz-uIf9CrM0ef1DpQUUFcUMkUXysaQUsTufhgK-lCeXsrTuTx9KE_vs-f5n1vcO361lQG2AClL_gLj76f_n_oTyQmm-g</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Jeon, Seong Gak</creator><creator>Kim, Yong Jun</creator><creator>Kim, Kyoung Ah</creator><creator>Mook-Jung, Inhee</creator><creator>Moon, Minho</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8140-5928</orcidid></search><sort><creationdate>20181001</creationdate><title>Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease</title><author>Jeon, Seong Gak ; Kim, Yong Jun ; Kim, Kyoung Ah ; Mook-Jung, Inhee ; Moon, Minho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-18597523e894f019dcc73ae4d53f36b291c39389beb143c0d0c8c2d7e9708fcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Cognitive ability</topic><topic>Cortex (entorhinal)</topic><topic>Disease Models, Animal</topic><topic>Entorhinal Cortex - pathology</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Locus coeruleus</topic><topic>Locus Coeruleus - pathology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Nerve Net - pathology</topic><topic>Neural networks</topic><topic>Neurobiology</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Neurosciences</topic><topic>Olfactory bulb</topic><topic>Olfactory Bulb - pathology</topic><topic>Olfactory stimuli</topic><topic>Perchlorate</topic><topic>Perchloric acid</topic><topic>Raphe Nuclei - pathology</topic><topic>Reproducibility of Results</topic><topic>Rodents</topic><topic>Septum</topic><topic>Substantia nigra</topic><topic>Substantia Nigra - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Seong Gak</au><au>Kim, Yong Jun</au><au>Kim, Kyoung Ah</au><au>Mook-Jung, Inhee</au><au>Moon, Minho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>55</volume><issue>10</issue><spage>7886</spage><epage>7899</epage><pages>7886-7899</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neurodegeneration in the hippocampus. Despite the pathological importance of the hippocampal degeneration in AD, little topographical evidence exists of impaired hippocampal connectivity in patients with AD. To investigate the anatomical connections of the hippocampus, we injected the neurotracer 1,1′-dioctadecyl-3,3,3′3,3′-tetramethyl-indocarbocyanine perchlorate (DiI) into the hippocampi of 5XFAD mice, which were used as an animal model of AD. In wild-type controls, DiI-containing cells were found in the entorhinal cortex, medial septum, locus coeruleus, dorsal raphe, substantia nigra pars compacta, and olfactory bulb. Hippocampal inputs were decreased in multiple brain regions in the 5XFAD mice compared to wild-type littermate mice. These results are the first to reveal alterations at the cellular level in hippocampal connectivity in the brains of 5XFAD mice. These results suggest that anatomical mapping of hippocampal connectivity will elucidate new pathogenic mechanisms and therapeutic targets for AD treatment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29488134</pmid><doi>10.1007/s12035-018-0918-y</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8140-5928</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer Disease - pathology Alzheimer's disease Animals Biomedical and Life Sciences Biomedicine Brain Cell Biology Cognitive ability Cortex (entorhinal) Disease Models, Animal Entorhinal Cortex - pathology Hippocampus Hippocampus - pathology Humans Locus coeruleus Locus Coeruleus - pathology Mice Mice, Transgenic Nerve Net - pathology Neural networks Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neurons - pathology Neurosciences Olfactory bulb Olfactory Bulb - pathology Olfactory stimuli Perchlorate Perchloric acid Raphe Nuclei - pathology Reproducibility of Results Rodents Septum Substantia nigra Substantia Nigra - pathology Visualization |
| title | Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease |
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