Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology
Summary Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on m...
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| Veröffentlicht in: | Neuropsychiatrie 2018-09, Vol.32 (3), p.149-158 |
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| creator | Foki, Thomas Hitzl, Daniela Pirker, Walter Novak, Klaus Pusswald, Gisela Lehrner, Johann |
| description | Summary
Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson’s patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination. Reliable change index methodology was used. Overall, there was cognitive change in individual patients, but the change was very heterogeneous with gains and losses. Further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases. |
| doi_str_mv | 10.1007/s40211-018-0271-4 |
| format | Article |
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Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson’s patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination. Reliable change index methodology was used. Overall, there was cognitive change in individual patients, but the change was very heterogeneous with gains and losses. Further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases.</description><identifier>ISSN: 0948-6259</identifier><identifier>EISSN: 2194-1327</identifier><identifier>DOI: 10.1007/s40211-018-0271-4</identifier><identifier>PMID: 29767379</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Cognition - physiology ; Cognitive Dysfunction ; Deep Brain Stimulation ; Humans ; Levodopa - administration & dosage ; Levodopa - adverse effects ; Levodopa - therapeutic use ; Medicine ; Medicine & Public Health ; Neurology ; Neuropsychological Tests ; Original ; Original Article ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; Parkinson Disease - surgery ; Parkinson Disease - therapy ; Psychiatry ; Psychotherapy ; Subthalamic Nucleus - physiology ; Treatment Outcome</subject><ispartof>Neuropsychiatrie, 2018-09, Vol.32 (3), p.149-158</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b7439852e0b530b8bed649854404dcab6fca9787695e31711fcbcc7e18bec47f3</citedby><cites>FETCH-LOGICAL-c508t-b7439852e0b530b8bed649854404dcab6fca9787695e31711fcbcc7e18bec47f3</cites><orcidid>0000-0001-8270-9272</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40211-018-0271-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40211-018-0271-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29767379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foki, Thomas</creatorcontrib><creatorcontrib>Hitzl, Daniela</creatorcontrib><creatorcontrib>Pirker, Walter</creatorcontrib><creatorcontrib>Novak, Klaus</creatorcontrib><creatorcontrib>Pusswald, Gisela</creatorcontrib><creatorcontrib>Lehrner, Johann</creatorcontrib><title>Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology</title><title>Neuropsychiatrie</title><addtitle>Neuropsychiatr</addtitle><addtitle>Neuropsychiatr</addtitle><description>Summary
Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson’s patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination. Reliable change index methodology was used. Overall, there was cognitive change in individual patients, but the change was very heterogeneous with gains and losses. Further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases.</description><subject>Cognition - physiology</subject><subject>Cognitive Dysfunction</subject><subject>Deep Brain Stimulation</subject><subject>Humans</subject><subject>Levodopa - administration & dosage</subject><subject>Levodopa - adverse effects</subject><subject>Levodopa - therapeutic use</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Original</subject><subject>Original Article</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson Disease - surgery</subject><subject>Parkinson Disease - therapy</subject><subject>Psychiatry</subject><subject>Psychotherapy</subject><subject>Subthalamic Nucleus - physiology</subject><subject>Treatment Outcome</subject><issn>0948-6259</issn><issn>2194-1327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAURS1EBdMpH8AG-QdcbMeJkw0SDJQiUYFou7Yc5yVjCPbITqadHb_R3-uX1KNQBBtWT_K79zzrXoQOGf3MKJXHUVDOGKGsJJRLRsQOmnFWCcIyLnfRjFaiJAXPq330McZ7SnMuC7mH9nmVZiarGfp15Rq7ts2oe2x85-xg14DNUrsOsG4HCPj87DuJY-ggbLB1-FaHB-uid3-f_kTc2Ag6Al7pwYIbIh6jdR2-g97quge8mEjpCvzG32BY-sb3vtt8Qh9a3Uc4eJ5z9PPLxY_FV3J9c3m1OL0mJqflQGopsqrMOdA6z2hd1tAUIj0IQUVjdF20RleylEWVQ8YkY62pjZHAktII2WZzdDJxV2P9CI1Jfwy6V6tgH3XYKK-tertxdqk6v1ZFylCUMgHYBDDBxxigffEyqrYtqKkFlVpQ2xaUSJ6j10dfHP9jTwI-CWJapXyCuvdjcCmId6j_AL0fl0A</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Foki, Thomas</creator><creator>Hitzl, Daniela</creator><creator>Pirker, Walter</creator><creator>Novak, Klaus</creator><creator>Pusswald, Gisela</creator><creator>Lehrner, Johann</creator><general>Springer Vienna</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8270-9272</orcidid></search><sort><creationdate>20180901</creationdate><title>Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology</title><author>Foki, Thomas ; Hitzl, Daniela ; Pirker, Walter ; Novak, Klaus ; Pusswald, Gisela ; Lehrner, Johann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b7439852e0b530b8bed649854404dcab6fca9787695e31711fcbcc7e18bec47f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cognition - physiology</topic><topic>Cognitive Dysfunction</topic><topic>Deep Brain Stimulation</topic><topic>Humans</topic><topic>Levodopa - administration & dosage</topic><topic>Levodopa - adverse effects</topic><topic>Levodopa - therapeutic use</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Original</topic><topic>Original Article</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson Disease - surgery</topic><topic>Parkinson Disease - therapy</topic><topic>Psychiatry</topic><topic>Psychotherapy</topic><topic>Subthalamic Nucleus - physiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foki, Thomas</creatorcontrib><creatorcontrib>Hitzl, Daniela</creatorcontrib><creatorcontrib>Pirker, Walter</creatorcontrib><creatorcontrib>Novak, Klaus</creatorcontrib><creatorcontrib>Pusswald, Gisela</creatorcontrib><creatorcontrib>Lehrner, Johann</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychiatrie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foki, Thomas</au><au>Hitzl, Daniela</au><au>Pirker, Walter</au><au>Novak, Klaus</au><au>Pusswald, Gisela</au><au>Lehrner, Johann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology</atitle><jtitle>Neuropsychiatrie</jtitle><stitle>Neuropsychiatr</stitle><addtitle>Neuropsychiatr</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>32</volume><issue>3</issue><spage>149</spage><epage>158</epage><pages>149-158</pages><issn>0948-6259</issn><eissn>2194-1327</eissn><abstract>Summary
Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson’s patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination. Reliable change index methodology was used. Overall, there was cognitive change in individual patients, but the change was very heterogeneous with gains and losses. Further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>29767379</pmid><doi>10.1007/s40211-018-0271-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8270-9272</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Cognition - physiology Cognitive Dysfunction Deep Brain Stimulation Humans Levodopa - administration & dosage Levodopa - adverse effects Levodopa - therapeutic use Medicine Medicine & Public Health Neurology Neuropsychological Tests Original Original Article Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson Disease - surgery Parkinson Disease - therapy Psychiatry Psychotherapy Subthalamic Nucleus - physiology Treatment Outcome |
| title | Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology |
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