MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion
Esophageal cancer ranks fourth in cancer‑associated mortality in China and the incidence of esophageal adenocarcinoma has risen dramatically over the past two decades. MicroRNA (miRNA/miR) serves a pivotal role in human cancer cell growth, invasion and migration. MiR‑675‑3p is highly expressed in es...
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| Veröffentlicht in: | Molecular medicine reports 2018-10, Vol.18 (4), p.3631-3640 |
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| creator | Xiao, Qi Chen, Tianming Wu, Yao Wu, Wenxiu Xu, Yandi Gong, Zhunan Chen, Shilin |
| description | Esophageal cancer ranks fourth in cancer‑associated mortality in China and the incidence of esophageal adenocarcinoma has risen dramatically over the past two decades. MicroRNA (miRNA/miR) serves a pivotal role in human cancer cell growth, invasion and migration. MiR‑675‑3p is highly expressed in esophageal squamous cell cancer (ESCC) tissues, and may have an influence on ESCC cell migration and invasion. ESCC tumor tissue samples from 35 patients were profiled. MiR‑675‑3p expression was confirmed by reverse transcription‑quantitative polymerase chain reaction. Manipulation of miR‑675‑3p via knockdown was carried out with subsequent evaluation of effects on cell proliferation, invasion, migration, and use of western blotting and ELISA assays. MiR‑675‑3p was overexpressed in ESCC tissues compared with normal tissues, and had higher expression levels in ESCC cells compared with the healthy esophageal epithelial cell line. The results revealed a predominant upregulation of cell migration and invasion ability. MiR‑675‑3p inhibitor inhibited ESCC cell proliferation, migration and invasion ability. It was also demonstrated that downregulation of miR‑675‑3p decreased the levels of matrix metalloproteinase (MMP) 2 and 9 and increased the level of E‑cadherin. In addition, the effects of miR‑675‑3p inhibitor on ESCC cell lines were eliminated by con‑transfection with miR‑675‑3p inhibitor and miR‑675‑3p mimic. In conclusion, the results indicated that miR‑675‑3p may be involved in the progression of ESCC through regulating ESCC cell migration and invasion capacity via modulating epithelial mesenchymal transition markers (MMP2, MMP 9 and E‑cadherin). |
| doi_str_mv | 10.3892/mmr.2018.9372 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A556966384</galeid><sourcerecordid>A556966384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-2a7081167b58327553b232c38c6341ff5242b20fb318ceb5ef00e8a8d4117b343</originalsourceid><addsrcrecordid>eNptUsFuFSEUJcbG1urSrZnEjZt5hcvAwMbkpWnVpNXEaOKOMDzmlWaAKcw0cddf8Bf9Epm8Z2uNIYELnHvg3HsQekXwigoJJ96nFWAiVpK28AQdkVaSmmLcPN3HIGV7iJ7nfI0xZ8DkM3RIMcGcMHaEvl86k-KXT-tfdz95y8pMx2pM0cfJ5srmOF7prdVDlW9m7eOcK2OHoTI6GJt2sXfbpCcXQ6XDpnLhVueyeYEOej1k-3K_HqNv52dfTz_UF5_ffzxdX9SmETDVoFssCOFtxwSFljHaAQVDheG0IX3PoIEOcN9RIoztmO0xtkKLTUNI29GGHqN3O95x7rzdGBumpAc1Jud1-qGidurxTXBXahtvFSeUNFIUgrd7ghRvZpsn5V1ehOlgi14FWAiQAIAL9M0_0Os4p1DkKSBYYlbqKh5QWz1Y5UIfy7tmIVVrxrjknIrl36v_oMrYWO9MDLZ35fxRQr1LKP3KOdn-XiPBarGCKlZQixXUYoWCf_13Ye7Rf3pPfwOAO676</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2109053018</pqid></control><display><type>article</type><title>MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Xiao, Qi ; Chen, Tianming ; Wu, Yao ; Wu, Wenxiu ; Xu, Yandi ; Gong, Zhunan ; Chen, Shilin</creator><creatorcontrib>Xiao, Qi ; Chen, Tianming ; Wu, Yao ; Wu, Wenxiu ; Xu, Yandi ; Gong, Zhunan ; Chen, Shilin</creatorcontrib><description>Esophageal cancer ranks fourth in cancer‑associated mortality in China and the incidence of esophageal adenocarcinoma has risen dramatically over the past two decades. MicroRNA (miRNA/miR) serves a pivotal role in human cancer cell growth, invasion and migration. MiR‑675‑3p is highly expressed in esophageal squamous cell cancer (ESCC) tissues, and may have an influence on ESCC cell migration and invasion. ESCC tumor tissue samples from 35 patients were profiled. MiR‑675‑3p expression was confirmed by reverse transcription‑quantitative polymerase chain reaction. Manipulation of miR‑675‑3p via knockdown was carried out with subsequent evaluation of effects on cell proliferation, invasion, migration, and use of western blotting and ELISA assays. MiR‑675‑3p was overexpressed in ESCC tissues compared with normal tissues, and had higher expression levels in ESCC cells compared with the healthy esophageal epithelial cell line. The results revealed a predominant upregulation of cell migration and invasion ability. MiR‑675‑3p inhibitor inhibited ESCC cell proliferation, migration and invasion ability. It was also demonstrated that downregulation of miR‑675‑3p decreased the levels of matrix metalloproteinase (MMP) 2 and 9 and increased the level of E‑cadherin. In addition, the effects of miR‑675‑3p inhibitor on ESCC cell lines were eliminated by con‑transfection with miR‑675‑3p inhibitor and miR‑675‑3p mimic. In conclusion, the results indicated that miR‑675‑3p may be involved in the progression of ESCC through regulating ESCC cell migration and invasion capacity via modulating epithelial mesenchymal transition markers (MMP2, MMP 9 and E‑cadherin).</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2018.9372</identifier><identifier>PMID: 30106155</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adenocarcinoma ; Aged ; Biomarkers ; Cancer metastasis ; Cancer research ; Cell growth ; Cell Growth Processes ; Cell migration ; Cell Movement ; Cell proliferation ; Chemotherapy ; E-cadherin ; Enzyme-linked immunosorbent assay ; Epithelial cells ; Epithelial-Mesenchymal Transition ; Esophageal cancer ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma - genetics ; Esophageal Squamous Cell Carcinoma - pathology ; Esophagus ; Female ; Gelatinase A ; Gelatinase B ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Genetic aspects ; Health aspects ; Humans ; Investigations ; Lung cancer ; Male ; Matrix metalloproteinase ; Medical prognosis ; Mesenchyme ; Metalloproteinase ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Mortality ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Physiological aspects ; Placenta ; Polymerase chain reaction ; Reverse transcription ; Squamous cell tumors ; Transfection ; Tumors ; Western blotting</subject><ispartof>Molecular medicine reports, 2018-10, Vol.18 (4), p.3631-3640</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Xiao et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-2a7081167b58327553b232c38c6341ff5242b20fb318ceb5ef00e8a8d4117b343</citedby><cites>FETCH-LOGICAL-c482t-2a7081167b58327553b232c38c6341ff5242b20fb318ceb5ef00e8a8d4117b343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30106155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Qi</creatorcontrib><creatorcontrib>Chen, Tianming</creatorcontrib><creatorcontrib>Wu, Yao</creatorcontrib><creatorcontrib>Wu, Wenxiu</creatorcontrib><creatorcontrib>Xu, Yandi</creatorcontrib><creatorcontrib>Gong, Zhunan</creatorcontrib><creatorcontrib>Chen, Shilin</creatorcontrib><title>MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Esophageal cancer ranks fourth in cancer‑associated mortality in China and the incidence of esophageal adenocarcinoma has risen dramatically over the past two decades. MicroRNA (miRNA/miR) serves a pivotal role in human cancer cell growth, invasion and migration. MiR‑675‑3p is highly expressed in esophageal squamous cell cancer (ESCC) tissues, and may have an influence on ESCC cell migration and invasion. ESCC tumor tissue samples from 35 patients were profiled. MiR‑675‑3p expression was confirmed by reverse transcription‑quantitative polymerase chain reaction. Manipulation of miR‑675‑3p via knockdown was carried out with subsequent evaluation of effects on cell proliferation, invasion, migration, and use of western blotting and ELISA assays. MiR‑675‑3p was overexpressed in ESCC tissues compared with normal tissues, and had higher expression levels in ESCC cells compared with the healthy esophageal epithelial cell line. The results revealed a predominant upregulation of cell migration and invasion ability. MiR‑675‑3p inhibitor inhibited ESCC cell proliferation, migration and invasion ability. It was also demonstrated that downregulation of miR‑675‑3p decreased the levels of matrix metalloproteinase (MMP) 2 and 9 and increased the level of E‑cadherin. In addition, the effects of miR‑675‑3p inhibitor on ESCC cell lines were eliminated by con‑transfection with miR‑675‑3p inhibitor and miR‑675‑3p mimic. In conclusion, the results indicated that miR‑675‑3p may be involved in the progression of ESCC through regulating ESCC cell migration and invasion capacity via modulating epithelial mesenchymal transition markers (MMP2, MMP 9 and E‑cadherin).</description><subject>Adenocarcinoma</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Cancer metastasis</subject><subject>Cancer research</subject><subject>Cell growth</subject><subject>Cell Growth Processes</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell proliferation</subject><subject>Chemotherapy</subject><subject>E-cadherin</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epithelial cells</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma - genetics</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Investigations</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Medical prognosis</subject><subject>Mesenchyme</subject><subject>Metalloproteinase</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Mortality</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>Squamous cell tumors</subject><subject>Transfection</subject><subject>Tumors</subject><subject>Western blotting</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUsFuFSEUJcbG1urSrZnEjZt5hcvAwMbkpWnVpNXEaOKOMDzmlWaAKcw0cddf8Bf9Epm8Z2uNIYELnHvg3HsQekXwigoJJ96nFWAiVpK28AQdkVaSmmLcPN3HIGV7iJ7nfI0xZ8DkM3RIMcGcMHaEvl86k-KXT-tfdz95y8pMx2pM0cfJ5srmOF7prdVDlW9m7eOcK2OHoTI6GJt2sXfbpCcXQ6XDpnLhVueyeYEOej1k-3K_HqNv52dfTz_UF5_ffzxdX9SmETDVoFssCOFtxwSFljHaAQVDheG0IX3PoIEOcN9RIoztmO0xtkKLTUNI29GGHqN3O95x7rzdGBumpAc1Jud1-qGidurxTXBXahtvFSeUNFIUgrd7ghRvZpsn5V1ehOlgi14FWAiQAIAL9M0_0Os4p1DkKSBYYlbqKh5QWz1Y5UIfy7tmIVVrxrjknIrl36v_oMrYWO9MDLZ35fxRQr1LKP3KOdn-XiPBarGCKlZQixXUYoWCf_13Ye7Rf3pPfwOAO676</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Xiao, Qi</creator><creator>Chen, Tianming</creator><creator>Wu, Yao</creator><creator>Wu, Wenxiu</creator><creator>Xu, Yandi</creator><creator>Gong, Zhunan</creator><creator>Chen, Shilin</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion</title><author>Xiao, Qi ; Chen, Tianming ; Wu, Yao ; Wu, Wenxiu ; Xu, Yandi ; Gong, Zhunan ; Chen, Shilin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-2a7081167b58327553b232c38c6341ff5242b20fb318ceb5ef00e8a8d4117b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Cancer metastasis</topic><topic>Cancer research</topic><topic>Cell growth</topic><topic>Cell Growth Processes</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Cell proliferation</topic><topic>Chemotherapy</topic><topic>E-cadherin</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epithelial cells</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma - genetics</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gelatinase A</topic><topic>Gelatinase B</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Investigations</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Medical prognosis</topic><topic>Mesenchyme</topic><topic>Metalloproteinase</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Mortality</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Physiological aspects</topic><topic>Placenta</topic><topic>Polymerase chain reaction</topic><topic>Reverse transcription</topic><topic>Squamous cell tumors</topic><topic>Transfection</topic><topic>Tumors</topic><topic>Western blotting</topic><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Qi</creatorcontrib><creatorcontrib>Chen, Tianming</creatorcontrib><creatorcontrib>Wu, Yao</creatorcontrib><creatorcontrib>Wu, Wenxiu</creatorcontrib><creatorcontrib>Xu, Yandi</creatorcontrib><creatorcontrib>Gong, Zhunan</creatorcontrib><creatorcontrib>Chen, Shilin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Qi</au><au>Chen, Tianming</au><au>Wu, Yao</au><au>Wu, Wenxiu</au><au>Xu, Yandi</au><au>Gong, Zhunan</au><au>Chen, Shilin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>18</volume><issue>4</issue><spage>3631</spage><epage>3640</epage><pages>3631-3640</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Esophageal cancer ranks fourth in cancer‑associated mortality in China and the incidence of esophageal adenocarcinoma has risen dramatically over the past two decades. MicroRNA (miRNA/miR) serves a pivotal role in human cancer cell growth, invasion and migration. MiR‑675‑3p is highly expressed in esophageal squamous cell cancer (ESCC) tissues, and may have an influence on ESCC cell migration and invasion. ESCC tumor tissue samples from 35 patients were profiled. MiR‑675‑3p expression was confirmed by reverse transcription‑quantitative polymerase chain reaction. Manipulation of miR‑675‑3p via knockdown was carried out with subsequent evaluation of effects on cell proliferation, invasion, migration, and use of western blotting and ELISA assays. MiR‑675‑3p was overexpressed in ESCC tissues compared with normal tissues, and had higher expression levels in ESCC cells compared with the healthy esophageal epithelial cell line. The results revealed a predominant upregulation of cell migration and invasion ability. MiR‑675‑3p inhibitor inhibited ESCC cell proliferation, migration and invasion ability. It was also demonstrated that downregulation of miR‑675‑3p decreased the levels of matrix metalloproteinase (MMP) 2 and 9 and increased the level of E‑cadherin. In addition, the effects of miR‑675‑3p inhibitor on ESCC cell lines were eliminated by con‑transfection with miR‑675‑3p inhibitor and miR‑675‑3p mimic. In conclusion, the results indicated that miR‑675‑3p may be involved in the progression of ESCC through regulating ESCC cell migration and invasion capacity via modulating epithelial mesenchymal transition markers (MMP2, MMP 9 and E‑cadherin).</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30106155</pmid><doi>10.3892/mmr.2018.9372</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Aged Biomarkers Cancer metastasis Cancer research Cell growth Cell Growth Processes Cell migration Cell Movement Cell proliferation Chemotherapy E-cadherin Enzyme-linked immunosorbent assay Epithelial cells Epithelial-Mesenchymal Transition Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - pathology Esophagus Female Gelatinase A Gelatinase B Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Health aspects Humans Investigations Lung cancer Male Matrix metalloproteinase Medical prognosis Mesenchyme Metalloproteinase Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Mortality Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Physiological aspects Placenta Polymerase chain reaction Reverse transcription Squamous cell tumors Transfection Tumors Western blotting |
| title | MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion |
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