Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant

The current study was designed to investigate the protective effect and possible mechanisms of umbelliferone (Umb) on liver injury in diabetic C57BL/KsJ-db/db (dbdb) mice. Mice were divided into five groups: wild-type mice group (WY), dbdb mice group, dbdb mice + Metformin (100 mg/kg) group, dbdb mi...

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Veröffentlicht in:	Bioscience reports 2018-08, Vol.38 (4)
Hauptverfasser:	Yin, Jiangning, Wang, Hanqing, Lu, Guoyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antioxidants - therapeutic use Diabetes Complications - blood Diabetes Complications - drug therapy Diabetes Complications - metabolism Diabetes Complications - pathology Liver - drug effects Liver - metabolism Liver - pathology Liver Diseases - blood Liver Diseases - drug therapy Liver Diseases - metabolism Liver Diseases - pathology Mice, Inbred C57BL NF-E2-Related Factor 2 - metabolism Signal Transduction - drug effects Umbelliferones - therapeutic use
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