Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats

Context: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis...

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Veröffentlicht in:Pharmaceutical biology 2017-01, Vol.55 (1), p.929-936
Hauptverfasser: Kouitcheu Mabeku, Laure Brigitte, Nanfack Nana, Blandine, Eyoum Bille, Bertrand, Tchuenteu Tchuenguem, Roland, Nguepi, Eveline
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container_issue 1
container_start_page 929
container_title Pharmaceutical biology
container_volume 55
creator Kouitcheu Mabeku, Laure Brigitte
Nanfack Nana, Blandine
Eyoum Bille, Bertrand
Tchuenteu Tchuenguem, Roland
Nguepi, Eveline
description Context: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. Objective: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents of peptic ulcer disease; Helicobacter pylori and non-steroidal anti-inflammatory drugs. Materials and methods: The anti-Helicobacter activity of A. pruinosum was evaluated using the broth microdilution method. After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days. Ulcer areas, gastric mucus content and nitric oxide gastric levels of animals were assessed 24 h after this treatment. Results: A. pruinosum extract shows a moderate anti-Helicobacter activity with an MIC value of 128 μg/mL. A. pruinosum extract, like Misoprostol and Maalox, markedly reduces the % of ulcerated area from 8.15 ± 0.33 to 1.71 ± 0.44% (500 mg/kg). It also increased significantly mucus and NO gastric production with respective values of 4.44 ± 1.35 and 965.81 ± 106.74 μmol/g (500 mg/kg). Discussion and conclusion: These findings suggest that A. pruinosum methanol extract possesses antiulcer properties as ascertained by the comparative decreases in ulcer areas, increase of mucus and NO gastric production.
doi_str_mv 10.1080/13880209.2017.1285326
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Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. Objective: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents of peptic ulcer disease; Helicobacter pylori and non-steroidal anti-inflammatory drugs. Materials and methods: The anti-Helicobacter activity of A. pruinosum was evaluated using the broth microdilution method. After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days. Ulcer areas, gastric mucus content and nitric oxide gastric levels of animals were assessed 24 h after this treatment. Results: A. pruinosum extract shows a moderate anti-Helicobacter activity with an MIC value of 128 μg/mL. A. pruinosum extract, like Misoprostol and Maalox, markedly reduces the % of ulcerated area from 8.15 ± 0.33 to 1.71 ± 0.44% (500 mg/kg). It also increased significantly mucus and NO gastric production with respective values of 4.44 ± 1.35 and 965.81 ± 106.74 μmol/g (500 mg/kg). Discussion and conclusion: These findings suggest that A. pruinosum methanol extract possesses antiulcer properties as ascertained by the comparative decreases in ulcer areas, increase of mucus and NO gastric production.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2017.1285326</identifier><identifier>PMID: 28164737</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Aframomum ; Aluminum Hydroxide - pharmacology ; Animals ; Anti-Bacterial Agents - isolation &amp; purification ; Anti-Bacterial Agents - pharmacology ; Anti-Ulcer Agents - pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Combinations ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gastritis ; Gastroduodenal diseases ; Helicobacter ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Helicobacter pylori - growth &amp; development ; herbal drugs ; Indomethacin ; Inflammation ; Magnesium Hydroxide - pharmacology ; Male ; Methanol ; Methanol - chemistry ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Misoprostol ; Misoprostol - pharmacology ; Mucus - metabolism ; Nitric oxide ; Nitric Oxide - metabolism ; non-steroidal anti-inflammatory drugs ; Nonsteroidal anti-inflammatory drugs ; Oral administration ; Peptic ulcers ; Phytotherapy ; Plant extracts ; Plants, Medicinal ; Rats, Sprague-Dawley ; Seeds ; Seeds - chemistry ; Solvents - chemistry ; Stomach Ulcer - chemically induced ; Stomach Ulcer - metabolism ; Stomach Ulcer - pathology ; Stomach Ulcer - prevention &amp; control ; Time Factors ; Ulcers ; Zingiberaceae - chemistry</subject><ispartof>Pharmaceutical biology, 2017-01, Vol.55 (1), p.929-936</ispartof><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. 2017</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 The Author(s). 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Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. Objective: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents of peptic ulcer disease; Helicobacter pylori and non-steroidal anti-inflammatory drugs. Materials and methods: The anti-Helicobacter activity of A. pruinosum was evaluated using the broth microdilution method. After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days. Ulcer areas, gastric mucus content and nitric oxide gastric levels of animals were assessed 24 h after this treatment. Results: A. pruinosum extract shows a moderate anti-Helicobacter activity with an MIC value of 128 μg/mL. A. pruinosum extract, like Misoprostol and Maalox, markedly reduces the % of ulcerated area from 8.15 ± 0.33 to 1.71 ± 0.44% (500 mg/kg). It also increased significantly mucus and NO gastric production with respective values of 4.44 ± 1.35 and 965.81 ± 106.74 μmol/g (500 mg/kg). Discussion and conclusion: These findings suggest that A. pruinosum methanol extract possesses antiulcer properties as ascertained by the comparative decreases in ulcer areas, increase of mucus and NO gastric production.</description><subject>Aframomum</subject><subject>Aluminum Hydroxide - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - isolation &amp; purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Combinations</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis</subject><subject>Gastroduodenal diseases</subject><subject>Helicobacter</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Helicobacter pylori - growth &amp; development</subject><subject>herbal drugs</subject><subject>Indomethacin</subject><subject>Inflammation</subject><subject>Magnesium Hydroxide - pharmacology</subject><subject>Male</subject><subject>Methanol</subject><subject>Methanol - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>Misoprostol</subject><subject>Misoprostol - pharmacology</subject><subject>Mucus - metabolism</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>non-steroidal anti-inflammatory drugs</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oral administration</subject><subject>Peptic ulcers</subject><subject>Phytotherapy</subject><subject>Plant extracts</subject><subject>Plants, Medicinal</subject><subject>Rats, Sprague-Dawley</subject><subject>Seeds</subject><subject>Seeds - chemistry</subject><subject>Solvents - chemistry</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - metabolism</subject><subject>Stomach Ulcer - pathology</subject><subject>Stomach Ulcer - prevention &amp; 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Nanfack Nana, Blandine ; Eyoum Bille, Bertrand ; Tchuenteu Tchuenguem, Roland ; Nguepi, Eveline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-514787313f11f62aab895afd89aa3b3bda8c86e97a6c37d19056431797db1ac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aframomum</topic><topic>Aluminum Hydroxide - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - isolation &amp; purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Combinations</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis</topic><topic>Gastroduodenal diseases</topic><topic>Helicobacter</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Helicobacter pylori - growth &amp; 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control</topic><topic>Time Factors</topic><topic>Ulcers</topic><topic>Zingiberaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouitcheu Mabeku, Laure Brigitte</creatorcontrib><creatorcontrib>Nanfack Nana, Blandine</creatorcontrib><creatorcontrib>Eyoum Bille, Bertrand</creatorcontrib><creatorcontrib>Tchuenteu Tchuenguem, Roland</creatorcontrib><creatorcontrib>Nguepi, Eveline</creatorcontrib><collection>Access via Taylor &amp; Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouitcheu Mabeku, Laure Brigitte</au><au>Nanfack Nana, Blandine</au><au>Eyoum Bille, Bertrand</au><au>Tchuenteu Tchuenguem, Roland</au><au>Nguepi, Eveline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>55</volume><issue>1</issue><spage>929</spage><epage>936</epage><pages>929-936</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Context: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. Objective: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents of peptic ulcer disease; Helicobacter pylori and non-steroidal anti-inflammatory drugs. Materials and methods: The anti-Helicobacter activity of A. pruinosum was evaluated using the broth microdilution method. After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days. Ulcer areas, gastric mucus content and nitric oxide gastric levels of animals were assessed 24 h after this treatment. Results: A. pruinosum extract shows a moderate anti-Helicobacter activity with an MIC value of 128 μg/mL. A. pruinosum extract, like Misoprostol and Maalox, markedly reduces the % of ulcerated area from 8.15 ± 0.33 to 1.71 ± 0.44% (500 mg/kg). It also increased significantly mucus and NO gastric production with respective values of 4.44 ± 1.35 and 965.81 ± 106.74 μmol/g (500 mg/kg). Discussion and conclusion: These findings suggest that A. pruinosum methanol extract possesses antiulcer properties as ascertained by the comparative decreases in ulcer areas, increase of mucus and NO gastric production.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>28164737</pmid><doi>10.1080/13880209.2017.1285326</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Aframomum
Aluminum Hydroxide - pharmacology
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Anti-Ulcer Agents - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Combinations
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastritis
Gastroduodenal diseases
Helicobacter
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - growth & development
herbal drugs
Indomethacin
Inflammation
Magnesium Hydroxide - pharmacology
Male
Methanol
Methanol - chemistry
Microbial Sensitivity Tests
Minimum inhibitory concentration
Misoprostol
Misoprostol - pharmacology
Mucus - metabolism
Nitric oxide
Nitric Oxide - metabolism
non-steroidal anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs
Oral administration
Peptic ulcers
Phytotherapy
Plant extracts
Plants, Medicinal
Rats, Sprague-Dawley
Seeds
Seeds - chemistry
Solvents - chemistry
Stomach Ulcer - chemically induced
Stomach Ulcer - metabolism
Stomach Ulcer - pathology
Stomach Ulcer - prevention & control
Time Factors
Ulcers
Zingiberaceae - chemistry
title Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats
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