SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

SS-31, a novel mitochondria-targeted peptide, has been proven to provide neuroprotection in a variety of neurological diseases. Its role as a mitochondrial reactive oxygen species (ROS) scavenger and the underlying pathophysiological mechanisms in traumatic brain injury (TBI) are still not well unde...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-12
Hauptverfasser:	Zhou, Mengliang, Zhou, Jiang, Dai, Wei, Fang, Jiang, Wang, Handong, Zhu, Yihao, Wang, Xiaoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Apoptosis Brain Brain Injuries, Traumatic - genetics Cytochrome c Deoxyribonucleic acid DNA Edema Homeostasis Hospitals Immunohistochemistry Injuries Laboratory animals Male Medical research Medicine, Experimental Metabolism Mice Mitochondria Mitochondria - metabolism Neuroprotection - drug effects Neuroprotective Agents Neurosciences Oligopeptides - pharmacology Oligopeptides - therapeutic use Oxidative stress Reactive oxygen species Reactive Oxygen Species - pharmacology Reactive Oxygen Species - therapeutic use Superoxide Traumatic brain injury
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