Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats

Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-12
Hauptverfasser:	Asakawa, Tetsuya, Li, Candong, Kang, Jie, Ding, Shan-Shan, Hu, Liu, Li, Guanhui, Li, Xihai, Liang, Wenna, Shen, Jianying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Biochemistry Biomarkers Biomechanics Bone biomechanics Bone marrow Bone mineral density Bone turnover Bones Cbfa-1 protein Chinese medicine Density Drug dosages Ethylenediaminetetraacetic acid Forkhead protein FOXO1 protein FOXO3 protein Gene expression Health aspects Herbal medicine Herbs Laboratory animals Medicine, Botanic Medicine, Herbal Metabolism miRNA Molecular modelling Morphology Osteoporosis Ovariectomy Peroxisome proliferator-activated receptors Post-menopause Postmenopausal women Rats Rodents SIRT1 protein Stem cells Therapeutic applications Transcription factors Vertebrae
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