Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats
Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat...
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| creator | Asakawa, Tetsuya Li, Candong Kang, Jie Ding, Shan-Shan Hu, Liu Li, Guanhui Li, Xihai Liang, Wenna Shen, Jianying |
| description | Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future. |
| doi_str_mv | 10.1155/2018/9210490 |
| format | Article |
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Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/9210490</identifier><identifier>PMID: 30224934</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adipocytes ; Biochemistry ; Biomarkers ; Biomechanics ; Bone biomechanics ; Bone marrow ; Bone mineral density ; Bone turnover ; Bones ; Cbfa-1 protein ; Chinese medicine ; Density ; Drug dosages ; Ethylenediaminetetraacetic acid ; Forkhead protein ; FOXO1 protein ; FOXO3 protein ; Gene expression ; Health aspects ; Herbal medicine ; Herbs ; Laboratory animals ; Medicine, Botanic ; Medicine, Herbal ; Metabolism ; miRNA ; Molecular modelling ; Morphology ; Osteoporosis ; Ovariectomy ; Peroxisome proliferator-activated receptors ; Post-menopause ; Postmenopausal women ; Rats ; Rodents ; SIRT1 protein ; Stem cells ; Therapeutic applications ; Transcription factors ; Vertebrae</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-12</ispartof><rights>Copyright © 2018 Wenna Liang et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Wenna Liang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Wenna Liang et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-93213f4dda102b7fdb71a2cd95769daf3c404419fb811daf588b7c02f701f36e3</citedby><cites>FETCH-LOGICAL-c565t-93213f4dda102b7fdb71a2cd95769daf3c404419fb811daf588b7c02f701f36e3</cites><orcidid>0000-0003-1799-4315 ; 0000-0002-2300-3509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129318/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129318/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30224934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cherniack, Evan P.</contributor><contributor>Evan P Cherniack</contributor><creatorcontrib>Asakawa, Tetsuya</creatorcontrib><creatorcontrib>Li, Candong</creatorcontrib><creatorcontrib>Kang, Jie</creatorcontrib><creatorcontrib>Ding, Shan-Shan</creatorcontrib><creatorcontrib>Hu, Liu</creatorcontrib><creatorcontrib>Li, Guanhui</creatorcontrib><creatorcontrib>Li, Xihai</creatorcontrib><creatorcontrib>Liang, Wenna</creatorcontrib><creatorcontrib>Shen, Jianying</creatorcontrib><title>Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.</description><subject>Adipocytes</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomechanics</subject><subject>Bone biomechanics</subject><subject>Bone marrow</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Bones</subject><subject>Cbfa-1 protein</subject><subject>Chinese medicine</subject><subject>Density</subject><subject>Drug dosages</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Forkhead protein</subject><subject>FOXO1 protein</subject><subject>FOXO3 protein</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Herbs</subject><subject>Laboratory animals</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Metabolism</subject><subject>miRNA</subject><subject>Molecular modelling</subject><subject>Morphology</subject><subject>Osteoporosis</subject><subject>Ovariectomy</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Rats</subject><subject>Rodents</subject><subject>SIRT1 protein</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Transcription 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asakawa, Tetsuya</au><au>Li, Candong</au><au>Kang, Jie</au><au>Ding, Shan-Shan</au><au>Hu, Liu</au><au>Li, Guanhui</au><au>Li, Xihai</au><au>Liang, Wenna</au><au>Shen, Jianying</au><au>Cherniack, Evan P.</au><au>Evan P Cherniack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30224934</pmid><doi>10.1155/2018/9210490</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1799-4315</orcidid><orcidid>https://orcid.org/0000-0002-2300-3509</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Adipocytes Biochemistry Biomarkers Biomechanics Bone biomechanics Bone marrow Bone mineral density Bone turnover Bones Cbfa-1 protein Chinese medicine Density Drug dosages Ethylenediaminetetraacetic acid Forkhead protein FOXO1 protein FOXO3 protein Gene expression Health aspects Herbal medicine Herbs Laboratory animals Medicine, Botanic Medicine, Herbal Metabolism miRNA Molecular modelling Morphology Osteoporosis Ovariectomy Peroxisome proliferator-activated receptors Post-menopause Postmenopausal women Rats Rodents SIRT1 protein Stem cells Therapeutic applications Transcription factors Vertebrae |
| title | Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats |
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