Challenges and recent progress in drug discovery for tropical diseases
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an...
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| Veröffentlicht in: | Nature (London) 2018-07, Vol.559 (7715), p.498-506 |
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| creator | De Rycker, Manu Baragaña, Beatriz Duce, Suzanne L. Gilbert, Ian H. |
| description | Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go. |
| doi_str_mv | 10.1038/s41586-018-0327-4 |
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These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. 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| subjects | 631/154/555 692/699/255 692/699/255/1715 Acquired immune deficiency syndrome AIDS Anemia Animals Beef cattle Biochemistry Blindness Coinfection Dehydration (Physiology) Diseases Drug development Drug discovery Drug Discovery - trends Drug resistance Drug therapy Drugs HIV Human immunodeficiency virus Humanities and Social Sciences Humans Infections - drug therapy Infections - microbiology Infections - parasitology Infections - virology Innovations Medical schools Morbidity multidisciplinary Nausea R&D Rash Research & development Review review-article Science Science (multidisciplinary) Studies Tropical Climate Tropical diseases Tropical Medicine - trends Universities and colleges |
| title | Challenges and recent progress in drug discovery for tropical diseases |
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