Human adipose beiging in response to cold and mirabegron

The induction of beige adipocytes in s.c. white adipose tissue (WAT) depots of humans is postulated to improve glucose and lipid metabolism in obesity. The ability of obese, insulin-resistant humans to induce beige adipose tissue is unknown. We exposed lean and obese research participants to cold (3...

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Veröffentlicht in:	JCI insight 2018-08, Vol.3 (15)
Hauptverfasser:	Finlin, Brian S, Memetimin, Hasiyet, Confides, Amy L, Kasza, Ildiko, Zhu, Beibei, Vekaria, Hemendra J, Harfmann, Brianna, Jones, Kelly A, Johnson, Zachary R, Westgate, Philip M, Alexander, Caroline M, Sullivan, Patrick G, Dupont-Versteegden, Esther E, Kern, Philip A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Acetanilides - therapeutic use Adipose Tissue, Beige - drug effects Adipose Tissue, Beige - metabolism Adipose Tissue, Beige - pathology Adrenergic beta-3 Receptor Agonists - pharmacology Adrenergic beta-3 Receptor Agonists - therapeutic use Adult Biopsy Clinical Medicine Cold Temperature - adverse effects Energy Metabolism - drug effects Energy Metabolism - physiology Female Humans Lipid Metabolism - drug effects Lipid Metabolism - physiology Male Membrane Proteins - metabolism Middle Aged Obesity - drug therapy Obesity - metabolism Obesity - pathology Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism Subcutaneous Fat - pathology Thermogenesis - physiology Thiazoles - pharmacology Thiazoles - therapeutic use Uncoupling Protein 1 - metabolism
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