Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia

New mechanisms behind blood cell formation continue to be uncovered, with therapeutic approaches for hematological diseases being of great interest. Here we report an enzyme in protein synthesis, known for cell-based activities beyond translation, is a factor inducing megakaryocyte-biased hematopoie...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-08, Vol.115 (35), p.E8228-E8235
Hauptverfasser:	Kanaji, Taisuke, Vo, My-Nuong, Kanaji, Sachiko, Zarpellon, Alessandro, Shapiro, Ryan, Morodomi, Yosuke, Yuzuriha, Akinori, Eto, Koji, Belani, Rajesh, Do, Minh-Ha, Yang, Xiang-Lei, Ruggeri, Zaverio M., Schimmel, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Biological Sciences Blood cells Blood Platelets - metabolism Blood Platelets - pathology Cell culture Cell Culture Techniques Cells Cells, Cultured Cytokines Enzymes Female Hematological diseases Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Immune system Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Male Megakaryocytes Megakaryocytes - metabolism Megakaryocytes - pathology Monocytes Mutagenesis MyD88 protein Platelets Ploidy Pluripotency PNAS Plus Polyploidy Protein biosynthesis Protein synthesis Proteins Replenishment Signal Transduction Splicing Stem cell transplantation Stem cells Thrombocytopenia Thrombocytopenia - metabolism Thrombocytopenia - pathology Thrombopoietin Thrombopoietin - metabolism Toll-like receptors Transfusion Transplantation tRNA Tyrosine-tRNA ligase Tyrosine-tRNA Ligase - metabolism
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