Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery
Purpose. To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods. A high-fat diet (HF) was giv...
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| creator | Karcz, Konrad Wojciech Garłowski, Wojciech Sawczyn, Tomasz Skrzep-Poloczek, Bronisława Chełmecka, Elżbieta Pigłowski, Wojciech Stygar, Dominika Jochem, Jerzy |
| description | Purpose. To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods. A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months. After that, half of each group underwent either DJOS or SHAM surgery. For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed. After 16 weeks of the experiment RBP4, fetuin-A, and FGF21 plasma levels as well as liver Rbp4, Ahsg, and Fgf21 gene expressions were measured. Results. DJOS had a reductive impact on plasma levels of RBP4, fetuin-A, and FGF21 and Rbp4, Ahsg, and Fgf21 relative gene expression in the liver when compared to SHAM. The HF/HF group expressed significantly higher RBP4 and fetuin-A plasma levels in comparison to the control. The HF diet used before and/or after surgery led to upregulation of Rbp4, Ahsg, and Fgf21 relative gene expression. The lowest levels of analyzed parameters were observed in the CD/CD group. Conclusions. The efficiency of DJOS surgery, measured by hepatokines’ plasma levels and their gene expressions in the liver, depends on the type of diet applied before and after surgery. Manipulation of dietary patterns can lead to marked improvements in metabolic profile after DJOS surgery. |
| doi_str_mv | 10.1155/2018/3472190 |
| format | Article |
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R. ; Ruth C R Meex</contributor><creatorcontrib>Karcz, Konrad Wojciech ; Garłowski, Wojciech ; Sawczyn, Tomasz ; Skrzep-Poloczek, Bronisława ; Chełmecka, Elżbieta ; Pigłowski, Wojciech ; Stygar, Dominika ; Jochem, Jerzy ; Meex, Ruth C. R. ; Ruth C R Meex</creatorcontrib><description>Purpose. To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods. A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months. After that, half of each group underwent either DJOS or SHAM surgery. For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed. After 16 weeks of the experiment RBP4, fetuin-A, and FGF21 plasma levels as well as liver Rbp4, Ahsg, and Fgf21 gene expressions were measured. Results. DJOS had a reductive impact on plasma levels of RBP4, fetuin-A, and FGF21 and Rbp4, Ahsg, and Fgf21 relative gene expression in the liver when compared to SHAM. The HF/HF group expressed significantly higher RBP4 and fetuin-A plasma levels in comparison to the control. The HF diet used before and/or after surgery led to upregulation of Rbp4, Ahsg, and Fgf21 relative gene expression. The lowest levels of analyzed parameters were observed in the CD/CD group. Conclusions. The efficiency of DJOS surgery, measured by hepatokines’ plasma levels and their gene expressions in the liver, depends on the type of diet applied before and after surgery. Manipulation of dietary patterns can lead to marked improvements in metabolic profile after DJOS surgery.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/3472190</identifier><identifier>PMID: 30211220</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>alpha-2-HS-Glycoprotein - metabolism ; Animals ; Bariatric Surgery ; Diabetes ; Diet ; Fibroblast growth factors ; Fibroblast Growth Factors - metabolism ; Fibroblasts ; Gastrointestinal surgery ; Gene expression ; Growth factors ; High fat diet ; Insulin resistance ; Lipids ; Liver ; Liver - metabolism ; Male ; Metabolic syndrome ; Obesity ; Physiology ; Plasma levels ; Proteins ; Rats ; Rats, Sprague-Dawley ; Retinol-binding protein ; Retinol-Binding Proteins, Plasma - metabolism ; Rodents ; Small intestine ; Surgery ; Transcriptome ; Vitamin A ; Weight control</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Dominika Stygar et al.</rights><rights>Copyright © 2018 Dominika Stygar et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Dominika Stygar et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-46a928154cf6ecb76568f7704ab6b127aa029558629e4b50eb2bec76b597c6ba3</citedby><cites>FETCH-LOGICAL-c471t-46a928154cf6ecb76568f7704ab6b127aa029558629e4b50eb2bec76b597c6ba3</cites><orcidid>0000-0001-8088-7681 ; 0000-0001-8509-7507 ; 0000-0002-3232-6377</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30211220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Meex, Ruth C. R.</contributor><contributor>Ruth C R Meex</contributor><creatorcontrib>Karcz, Konrad Wojciech</creatorcontrib><creatorcontrib>Garłowski, Wojciech</creatorcontrib><creatorcontrib>Sawczyn, Tomasz</creatorcontrib><creatorcontrib>Skrzep-Poloczek, Bronisława</creatorcontrib><creatorcontrib>Chełmecka, Elżbieta</creatorcontrib><creatorcontrib>Pigłowski, Wojciech</creatorcontrib><creatorcontrib>Stygar, Dominika</creatorcontrib><creatorcontrib>Jochem, Jerzy</creatorcontrib><title>Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Purpose. To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods. A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months. After that, half of each group underwent either DJOS or SHAM surgery. For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed. After 16 weeks of the experiment RBP4, fetuin-A, and FGF21 plasma levels as well as liver Rbp4, Ahsg, and Fgf21 gene expressions were measured. Results. DJOS had a reductive impact on plasma levels of RBP4, fetuin-A, and FGF21 and Rbp4, Ahsg, and Fgf21 relative gene expression in the liver when compared to SHAM. The HF/HF group expressed significantly higher RBP4 and fetuin-A plasma levels in comparison to the control. The HF diet used before and/or after surgery led to upregulation of Rbp4, Ahsg, and Fgf21 relative gene expression. The lowest levels of analyzed parameters were observed in the CD/CD group. Conclusions. The efficiency of DJOS surgery, measured by hepatokines’ plasma levels and their gene expressions in the liver, depends on the type of diet applied before and after surgery. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karcz, Konrad Wojciech</au><au>Garłowski, Wojciech</au><au>Sawczyn, Tomasz</au><au>Skrzep-Poloczek, Bronisława</au><au>Chełmecka, Elżbieta</au><au>Pigłowski, Wojciech</au><au>Stygar, Dominika</au><au>Jochem, Jerzy</au><au>Meex, Ruth C. R.</au><au>Ruth C R Meex</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Purpose. To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods. A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months. After that, half of each group underwent either DJOS or SHAM surgery. For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed. After 16 weeks of the experiment RBP4, fetuin-A, and FGF21 plasma levels as well as liver Rbp4, Ahsg, and Fgf21 gene expressions were measured. Results. DJOS had a reductive impact on plasma levels of RBP4, fetuin-A, and FGF21 and Rbp4, Ahsg, and Fgf21 relative gene expression in the liver when compared to SHAM. The HF/HF group expressed significantly higher RBP4 and fetuin-A plasma levels in comparison to the control. The HF diet used before and/or after surgery led to upregulation of Rbp4, Ahsg, and Fgf21 relative gene expression. The lowest levels of analyzed parameters were observed in the CD/CD group. Conclusions. The efficiency of DJOS surgery, measured by hepatokines’ plasma levels and their gene expressions in the liver, depends on the type of diet applied before and after surgery. Manipulation of dietary patterns can lead to marked improvements in metabolic profile after DJOS surgery.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30211220</pmid><doi>10.1155/2018/3472190</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8088-7681</orcidid><orcidid>https://orcid.org/0000-0001-8509-7507</orcidid><orcidid>https://orcid.org/0000-0002-3232-6377</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | alpha-2-HS-Glycoprotein - metabolism Animals Bariatric Surgery Diabetes Diet Fibroblast growth factors Fibroblast Growth Factors - metabolism Fibroblasts Gastrointestinal surgery Gene expression Growth factors High fat diet Insulin resistance Lipids Liver Liver - metabolism Male Metabolic syndrome Obesity Physiology Plasma levels Proteins Rats Rats, Sprague-Dawley Retinol-binding protein Retinol-Binding Proteins, Plasma - metabolism Rodents Small intestine Surgery Transcriptome Vitamin A Weight control |
| title | Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery |
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