SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium

The cell of origin of colon cancer is typically thought to be the resident somatic stem cells, which are immortal and escape the continual cellular turnover characteristic of the intestinal epithelium. However, recent studies have identified certain conditions in which differentiated cells can acqui...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-09, Vol.78 (17), p.4878-4890
Hauptverfasser:	Perekatt, Ansu O, Shah, Pooja P, Cheung, Shannon, Jariwala, Nidhi, Wu, Alex, Gandhi, Vishal, Kumar, Namit, Feng, Qiang, Patel, Neeket, Chen, Lei, Joshi, Shilpy, Zhou, Anbo, Taketo, M Mark, Xing, Jinchuan, White, Eileen, Gao, Nan, Gatza, Michael L, Verzi, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Animals Carcinogenesis - genetics Cell Dedifferentiation - genetics Cell Differentiation - genetics Colonic Neoplasms - genetics Colonic Neoplasms - pathology Disease Models, Animal Enterocytes - metabolism Enterocytes - pathology Female Gene Expression Regulation, Neoplastic Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Mice Neoplasm Proteins - genetics Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Smad4 Protein - genetics Wnt Signaling Pathway - genetics
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